Leishmanicidal activity of two naphthoquinones against Leishmania donovani

Claudio Manuel Lezama-Dávila, Angelica Patricia Isaac-Márquez, Govind Kapadia, Katherine Owens, Steve Oghumu, Stephen Beverley, Abhay Rajaninath Satoskar

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values compare well to those obtained with the standard first-line antileishmanial agent sodium stibogluconate (SSG). TR 001 also induced significantly more nitric oxide (NO) production than TR 002 or SSG. Taken together, these data show that TR 001 and TR 002 could be promising new drugs for treatment of visceral leishmaniasis.

Original languageEnglish
Pages (from-to)1761-1764
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume35
Issue number10
DOIs
StatePublished - Oct 1 2012

Keywords

  • Leishmania
  • Macrophage
  • Naphthoquinone

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    Lezama-Dávila, C. M., Isaac-Márquez, A. P., Kapadia, G., Owens, K., Oghumu, S., Beverley, S., & Satoskar, A. R. (2012). Leishmanicidal activity of two naphthoquinones against Leishmania donovani. Biological and Pharmaceutical Bulletin, 35(10), 1761-1764. https://doi.org/10.1248/bpb.b12-00419