TY - JOUR
T1 - Leishmanicidal activity of two naphthoquinones against Leishmania donovani
AU - Lezama-Dávila, Claudio Manuel
AU - Isaac-Márquez, Angelica Patricia
AU - Kapadia, Govind
AU - Owens, Katherine
AU - Oghumu, Steve
AU - Beverley, Stephen
AU - Satoskar, Abhay Rajaninath
PY - 2012/10
Y1 - 2012/10
N2 - Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values compare well to those obtained with the standard first-line antileishmanial agent sodium stibogluconate (SSG). TR 001 also induced significantly more nitric oxide (NO) production than TR 002 or SSG. Taken together, these data show that TR 001 and TR 002 could be promising new drugs for treatment of visceral leishmaniasis.
AB - Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values compare well to those obtained with the standard first-line antileishmanial agent sodium stibogluconate (SSG). TR 001 also induced significantly more nitric oxide (NO) production than TR 002 or SSG. Taken together, these data show that TR 001 and TR 002 could be promising new drugs for treatment of visceral leishmaniasis.
KW - Leishmania
KW - Macrophage
KW - Naphthoquinone
UR - http://www.scopus.com/inward/record.url?scp=84867248213&partnerID=8YFLogxK
U2 - 10.1248/bpb.b12-00419
DO - 10.1248/bpb.b12-00419
M3 - Article
C2 - 23037165
AN - SCOPUS:84867248213
SN - 0918-6158
VL - 35
SP - 1761
EP - 1764
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
IS - 10
ER -