TY - JOUR
T1 - Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice
AU - Späth, Gerald F.
AU - McDowell, Mary Ann
AU - Beverley, Stephen M.
N1 - Funding Information:
CD45 −/− and me v mice were generously provided by Dr. Matthew Thomas and Dr. Eric Brown, Washington University School of Medicine, St. Louis. MO. We thank Tamara Roach for discussion and help in macrophage isolation. This work was supported by the Deutsche Akademischer Austauschdienst and The Human Frontiers Science Program (GFS), NIH Grant AI056242 and AHA Grant #0435333Z (MAM) and NIH Grant AI31078 (SMB).
PY - 2008/11
Y1 - 2008/11
N2 - Protozoan parasites of the genus Leishmania escape from the immune response by interfering with signal transduction pathways of its host cell, the macrophage, thereby establishing permissive conditions for intracellular survival. Inhibition of macrophage activation after Leishmania infection has been suggested to require activation of the host cell phosphatase SHP-1. However, by utilizing infections of SHP-1 deficient (mev) and CD45 null mutant mice or macrophages, we provide evidence that intracellular survival of Leishmania major is not generally dependent on these cellular phosphatases.
AB - Protozoan parasites of the genus Leishmania escape from the immune response by interfering with signal transduction pathways of its host cell, the macrophage, thereby establishing permissive conditions for intracellular survival. Inhibition of macrophage activation after Leishmania infection has been suggested to require activation of the host cell phosphatase SHP-1. However, by utilizing infections of SHP-1 deficient (mev) and CD45 null mutant mice or macrophages, we provide evidence that intracellular survival of Leishmania major is not generally dependent on these cellular phosphatases.
KW - Cellular phosphatases
KW - Host cell signaling pathways
KW - Immune subversion
KW - Intracellular parasite
KW - Leishmania major
KW - Macrophage
KW - Trypanosomatid protozoa
UR - http://www.scopus.com/inward/record.url?scp=53049089586&partnerID=8YFLogxK
U2 - 10.1016/j.exppara.2008.07.003
DO - 10.1016/j.exppara.2008.07.003
M3 - Article
C2 - 18682252
AN - SCOPUS:53049089586
SN - 0014-4894
VL - 120
SP - 275
EP - 279
JO - Experimental Parasitology
JF - Experimental Parasitology
IS - 3
ER -