TY - JOUR
T1 - Left ventricular systolic dysfunction in a biracial sample of hypertensive adults
T2 - The HyperGEN study
AU - Devereux, Richard B.
AU - Bella, Jonathan N.
AU - Palmieri, Vittorio
AU - Oberman, Albert
AU - Kitzman, Dalane W.
AU - Hopkins, Paul N.
AU - Rao, D. C.
AU - Morgan, Derek
AU - Paranicas, Mary
AU - Fishman, Dawn
AU - Arnett, Donna K.
PY - 2001
Y1 - 2001
N2 - To determine the prevalence and correlates of left ventricular systolic dysfunction in hypertensive patients in a biracial population-based sample, clinical evaluation and echocardiography were performed in 2086 participants in the Hypertension Genetic Epidemiology Network (HyperGEN) examination; 86% had normal ejection fraction (>54%), 10% had mild ventricular dysfunction (ejection fraction 41% to 54%), and 4% had severe ventricular dysfunction (ejection fraction <40%). Prevalences of mild and severe ventricular dysfunction were higher in men than women (14% versus 8% and 7% versus 3%, P<0.001) and, weakly, in diabetics than nondiabetics (13% versus 10% and 6% versus 4%, P=0.07). Patients with severe ventricular dysfunction were older than those with mild dysfunction or normal function (mean, 58 versus 54 and 54 years, respectively; P=0.005) and had higher mean creatinine (1.20 versus 1.05 and 1.00 mg/dL) and uric acid (6.9 versus 6.3 and 6.1 mg/dL) levels (both P<0.001). Those with severe ventricular dysfunction, compared with those with mild dysfunction or normal ejection fraction, had greater mean ventricular internal dimension (6.2 versus 5.6 and 5.1 cm) and mass (61 versus 50 and 43 g/m2.7) and lower relative wall thickness (0.31 versus 33 and 0.35; all P<0.0001). Severe and mild ventricular dysfunction was associated with lower myocardial contractility (mean stress-corrected midwall shortening, 68% versus 94% versus 106% of predicted; P<0.0001). In regression analyses, lower ejection fraction as a continuous variable was independently and positively associated with male gender, diabetes, uric acid level, and body mass index. With the addition of echocardiographic variables, lower ejection fraction was associated with male gender, black race, prior myocardial infarction, and higher ventricular mass and lower relative wall thickness, pulse pressure, and body mass index. In a population-based sample of hypertensive patients, left ventricular systolic dysfunction was related to male gender, black race, diabetes, and elevated uric acid levels, as well as higher ventricular mass and lower relative wall thickness.
AB - To determine the prevalence and correlates of left ventricular systolic dysfunction in hypertensive patients in a biracial population-based sample, clinical evaluation and echocardiography were performed in 2086 participants in the Hypertension Genetic Epidemiology Network (HyperGEN) examination; 86% had normal ejection fraction (>54%), 10% had mild ventricular dysfunction (ejection fraction 41% to 54%), and 4% had severe ventricular dysfunction (ejection fraction <40%). Prevalences of mild and severe ventricular dysfunction were higher in men than women (14% versus 8% and 7% versus 3%, P<0.001) and, weakly, in diabetics than nondiabetics (13% versus 10% and 6% versus 4%, P=0.07). Patients with severe ventricular dysfunction were older than those with mild dysfunction or normal function (mean, 58 versus 54 and 54 years, respectively; P=0.005) and had higher mean creatinine (1.20 versus 1.05 and 1.00 mg/dL) and uric acid (6.9 versus 6.3 and 6.1 mg/dL) levels (both P<0.001). Those with severe ventricular dysfunction, compared with those with mild dysfunction or normal ejection fraction, had greater mean ventricular internal dimension (6.2 versus 5.6 and 5.1 cm) and mass (61 versus 50 and 43 g/m2.7) and lower relative wall thickness (0.31 versus 33 and 0.35; all P<0.0001). Severe and mild ventricular dysfunction was associated with lower myocardial contractility (mean stress-corrected midwall shortening, 68% versus 94% versus 106% of predicted; P<0.0001). In regression analyses, lower ejection fraction as a continuous variable was independently and positively associated with male gender, diabetes, uric acid level, and body mass index. With the addition of echocardiographic variables, lower ejection fraction was associated with male gender, black race, prior myocardial infarction, and higher ventricular mass and lower relative wall thickness, pulse pressure, and body mass index. In a population-based sample of hypertensive patients, left ventricular systolic dysfunction was related to male gender, black race, diabetes, and elevated uric acid levels, as well as higher ventricular mass and lower relative wall thickness.
KW - Diabetes
KW - Diastole
KW - Echocardiography
KW - Hypertension
KW - Ventricular dysfunction
UR - http://www.scopus.com/inward/record.url?scp=0035569851&partnerID=8YFLogxK
U2 - 10.1161/01.HYP.38.3.417
DO - 10.1161/01.HYP.38.3.417
M3 - Article
C2 - 11566915
AN - SCOPUS:0035569851
SN - 0194-911X
VL - 38
SP - 417
EP - 423
JO - Hypertension
JF - Hypertension
IS - 3
ER -