TY - JOUR
T1 - Left ventricular size and shape
T2 - Determinants of mechanical signal transduction pathways
AU - Mann, Douglas L.
N1 - Funding Information:
The author would like to thank Mary Helen Soliz for secretarial support. This work was supported, in part, by research funds from the N.I.H. (P50 HL-O6H and RO1 HL58081-01, RO1 HL61543-01, HL-42250-10/10).
PY - 2005/6
Y1 - 2005/6
N2 - Heart failure may be viewed as a progressive disorder that is impelled, at least in part, by progressive left ventricular (LV) remodeling. In the present discussion we will review the role of LV remodeling in the pathogenesis of heart failure, with a focus on the contribution that changes in LV size and shape play in the development and progression of the progression of heart failure. The clinical implication of this review is that existing neurohormonal strategies may not completely prevent disease progression in the failing heart, and that adjunctive strategies that are designed to specifically prevent and/or attenuate LV remodeling may play an important role in the clinical treatment of heart failure.
AB - Heart failure may be viewed as a progressive disorder that is impelled, at least in part, by progressive left ventricular (LV) remodeling. In the present discussion we will review the role of LV remodeling in the pathogenesis of heart failure, with a focus on the contribution that changes in LV size and shape play in the development and progression of the progression of heart failure. The clinical implication of this review is that existing neurohormonal strategies may not completely prevent disease progression in the failing heart, and that adjunctive strategies that are designed to specifically prevent and/or attenuate LV remodeling may play an important role in the clinical treatment of heart failure.
KW - Heart failure
KW - Left ventricular remodeling
KW - Stretch
KW - Wall stress
UR - http://www.scopus.com/inward/record.url?scp=27944461888&partnerID=8YFLogxK
U2 - 10.1007/s10741-005-4636-y
DO - 10.1007/s10741-005-4636-y
M3 - Article
C2 - 16258716
AN - SCOPUS:27944461888
SN - 1382-4147
VL - 10
SP - 95
EP - 100
JO - Heart Failure Reviews
JF - Heart Failure Reviews
IS - 2
ER -