TY - JOUR
T1 - Left ventricular mass index is an independent determinant of diastolic dysfunction in patients on chronic hemodialysis
T2 - A tissue doppler imaging study
AU - Kimura, Hiroshi
AU - Takeda, Kazuhito
AU - Tsuruya, Kazuhiko
AU - Mukai, Hideyuki
AU - Muto, Yoshiharu
AU - Okuda, Hiroshi
AU - Furusho, Masahide
AU - Ueno, Toshiharu
AU - Nakashita, Satsuki
AU - Miura, Shuhei
AU - Maeda, Atsuhiro
AU - Kondo, Hideki
PY - 2010/12
Y1 - 2010/12
N2 - Background: Diastolic heart failure is the most common clinical form of heart failure. Tissue Doppler imaging (TDI) is often used to quantitate left ventricular (LV) diastolic function. The purpose of this study was to identify the determinant(s) of diastolic dysfunction in patients with end-stage renal disease on hemodialysis (HD), using the TDI method. Methods: The study subjects were 53 patients with end-stage renal disease and preserved LV systolic function on maintenance HD. LV function was assessed by conventional echocardiography. The ratio of early trans-mitral flow velocity to early mitral annular velocity (E/e′) was measured by TDI. Patients were stratified into two groups based on E/e′ value (≤15 and >15 groups). Arterial stiffness was evaluated by pulse wave velocity and cardio-ankle vascular index. Results: Patients of the E/e′ >15 group were older (p = 0.025). There were no significant differences in blood pressure, ejection fraction, E/A, deceleration time, and pulse wave velocity between the E/e′ >15 and E/e′ ≤15 groups. However, there were significant differences in LV mass index (LVMI; p < 0.001) and cardio-ankle vascular index (p = 0.048) between the two groups. Multiple regression analysis identified that LVMI was an independent determinant of E/e′ (p = 0.003). Conclusions:Our findings suggest that LVMI is an independent determinant of LV diastolic dysfunction in patients on HD.
AB - Background: Diastolic heart failure is the most common clinical form of heart failure. Tissue Doppler imaging (TDI) is often used to quantitate left ventricular (LV) diastolic function. The purpose of this study was to identify the determinant(s) of diastolic dysfunction in patients with end-stage renal disease on hemodialysis (HD), using the TDI method. Methods: The study subjects were 53 patients with end-stage renal disease and preserved LV systolic function on maintenance HD. LV function was assessed by conventional echocardiography. The ratio of early trans-mitral flow velocity to early mitral annular velocity (E/e′) was measured by TDI. Patients were stratified into two groups based on E/e′ value (≤15 and >15 groups). Arterial stiffness was evaluated by pulse wave velocity and cardio-ankle vascular index. Results: Patients of the E/e′ >15 group were older (p = 0.025). There were no significant differences in blood pressure, ejection fraction, E/A, deceleration time, and pulse wave velocity between the E/e′ >15 and E/e′ ≤15 groups. However, there were significant differences in LV mass index (LVMI; p < 0.001) and cardio-ankle vascular index (p = 0.048) between the two groups. Multiple regression analysis identified that LVMI was an independent determinant of E/e′ (p = 0.003). Conclusions:Our findings suggest that LVMI is an independent determinant of LV diastolic dysfunction in patients on HD.
KW - Diastolic dysfunction
KW - Early mitral annular velocity
KW - Early trans-mitral flow velocity
KW - Hemodialysis
KW - Left ventricular mass index
UR - http://www.scopus.com/inward/record.url?scp=77955120374&partnerID=8YFLogxK
U2 - 10.1159/000319649
DO - 10.1159/000319649
M3 - Article
C2 - 20689327
AN - SCOPUS:77955120374
SN - 1660-2110
VL - 117
SP - c67-c73
JO - Nephron - Clinical Practice
JF - Nephron - Clinical Practice
IS - 1
ER -