TY - JOUR
T1 - Left ventricular diastolic suction with zero left atrial pressure in open-chest dogs
AU - Ingels, Neil B.
AU - Daughters, George T.
AU - Nikolic, Srdjan D.
AU - DeAnda, Abe
AU - Moon, Marc R.
AU - Bolger, Ann F.
AU - Komeda, Masashi
AU - Derby, Geraldine C.
AU - Yellin, Edward L.
AU - Miller, D. Craig
PY - 1996
Y1 - 1996
N2 - We investigated left ventricular (LV) diastolic volume changes (suction inflows) with left atrial pressure (LAP) clamped to ambient pressure in six open-chest, anesthetized dogs. The left atrium was cannulated and connected to a servo pump, and LAP was clamped to a set point near 0 mmHg for four beats by withdrawing blood. LAP averaged 5.88 ± 1.44 mmHg before the clamp and fell to 0.74 ± 0.61 mmHg (P < 0.0001) after the clamp. During the first clamped beat a transmitral pressure gradient of 1.0 ± 0.6 mmHg was observed, resulting in LV filling of 2.6 ± 1.8 ml. Subsequent beats developed suction-driven (mean negative LV pressure: -1.5 ± 1.3 mmHg; P < 0.005 vs. zero) LV filling of 4.5 ± 2.8 ml/beat with a peak transmitral pressure gradient of 1.7 ± 0.6 mmHg. These data are consistent with the hypothesis that LV suction can be an important filling mechanism under conditions in which LV end-systolic volume is reduced, e.g., reduced filling pressures, high heart rates, exercise, or increased inotropic drive.
AB - We investigated left ventricular (LV) diastolic volume changes (suction inflows) with left atrial pressure (LAP) clamped to ambient pressure in six open-chest, anesthetized dogs. The left atrium was cannulated and connected to a servo pump, and LAP was clamped to a set point near 0 mmHg for four beats by withdrawing blood. LAP averaged 5.88 ± 1.44 mmHg before the clamp and fell to 0.74 ± 0.61 mmHg (P < 0.0001) after the clamp. During the first clamped beat a transmitral pressure gradient of 1.0 ± 0.6 mmHg was observed, resulting in LV filling of 2.6 ± 1.8 ml. Subsequent beats developed suction-driven (mean negative LV pressure: -1.5 ± 1.3 mmHg; P < 0.005 vs. zero) LV filling of 4.5 ± 2.8 ml/beat with a peak transmitral pressure gradient of 1.7 ± 0.6 mmHg. These data are consistent with the hypothesis that LV suction can be an important filling mechanism under conditions in which LV end-systolic volume is reduced, e.g., reduced filling pressures, high heart rates, exercise, or increased inotropic drive.
KW - Left atrial pressure clamp
KW - Left atrium
KW - Left ventricle
KW - Left ventricular diastolic filling
UR - http://www.scopus.com/inward/record.url?scp=18244416182&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.1996.270.4.h1217
DO - 10.1152/ajpheart.1996.270.4.h1217
M3 - Article
C2 - 8967359
AN - SCOPUS:18244416182
SN - 0363-6135
VL - 270
SP - H1217-H1224
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 4 39-4
ER -