TY - JOUR
T1 - Left ventricular diastolic filling in patients with left ventricular dysfunction
AU - Lavine, Steven J.
AU - Krishnaswami, Venkataraman
AU - Shreiner, David P.
AU - Amidi, Morteza
PY - 1985/8
Y1 - 1985/8
N2 - The pattern of abnormal left ventricular diastolic filling and its specificity in coronary disease patients with severe left ventricular dysfunction has received little attention. We evaluated the left ventricular diastolic filling curve derived from gated blood pool scans in 21 normals, 61 coronary disease patients with ejection fractions ≤30%, and 51 congestive cardiomyopathy patients with ejection fraction ≤30%. The peak filling rate (PFR), peak ejection rate (PER), PER PER and the % stroke volume filled at 1 3 of diastole (%SV- 1 3 DT) and at the end of the rapid filling period (%SV-RFP) were determined for each group. The PFR and PER were reduced in both coronary disease and congestive cardiomyopathy groups. The PFR PER was increased in the coronary disease group (1.19 ± 0.28) and congestive cardiomyopathy group (1.21 ± 0.32) as compared to normals (0.93 ± 0.20, P < 0.001). A greater %SV- 1 3 DT and %SV-RFP were noted in both coronary disease and congestive cardiomyopathy groups. Coronary disease and congestive cardiomyopathy patients with a mean pulmonary capillary pressure (PCP) ≥ 18 mm Hg had a greater PFR PER, %SV- 1 3 DT, and %SV-RFP than patients with a PCP < 18 mm Hg. An abnormal and nonspecific pattern of left ventricular diastolic filling is present in both coronary disease and congestive cardiomyopathy patients and is characterized by an increased FER PER, a greater %SV- 1 3 DT, and a greater %SV-RFP. This pattern may be related to elevated PCPs.
AB - The pattern of abnormal left ventricular diastolic filling and its specificity in coronary disease patients with severe left ventricular dysfunction has received little attention. We evaluated the left ventricular diastolic filling curve derived from gated blood pool scans in 21 normals, 61 coronary disease patients with ejection fractions ≤30%, and 51 congestive cardiomyopathy patients with ejection fraction ≤30%. The peak filling rate (PFR), peak ejection rate (PER), PER PER and the % stroke volume filled at 1 3 of diastole (%SV- 1 3 DT) and at the end of the rapid filling period (%SV-RFP) were determined for each group. The PFR and PER were reduced in both coronary disease and congestive cardiomyopathy groups. The PFR PER was increased in the coronary disease group (1.19 ± 0.28) and congestive cardiomyopathy group (1.21 ± 0.32) as compared to normals (0.93 ± 0.20, P < 0.001). A greater %SV- 1 3 DT and %SV-RFP were noted in both coronary disease and congestive cardiomyopathy groups. Coronary disease and congestive cardiomyopathy patients with a mean pulmonary capillary pressure (PCP) ≥ 18 mm Hg had a greater PFR PER, %SV- 1 3 DT, and %SV-RFP than patients with a PCP < 18 mm Hg. An abnormal and nonspecific pattern of left ventricular diastolic filling is present in both coronary disease and congestive cardiomyopathy patients and is characterized by an increased FER PER, a greater %SV- 1 3 DT, and a greater %SV-RFP. This pattern may be related to elevated PCPs.
KW - coronary artery disease
KW - left ventricular dysfunction
KW - left ventricular filling)
UR - http://www.scopus.com/inward/record.url?scp=0021864567&partnerID=8YFLogxK
U2 - 10.1016/0167-5273(85)90119-6
DO - 10.1016/0167-5273(85)90119-6
M3 - Article
C2 - 4030145
AN - SCOPUS:0021864567
VL - 8
SP - 423
EP - 436
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 4
ER -