TY - JOUR
T1 - Left ventricular diastolic filling and its association with age
AU - Miller, Tom R.
AU - Grossman, Stanley J.
AU - Schectman, Kenneth B.
AU - Biello, Daniel R.
AU - Ludbrook, Philip A.
AU - Ehsani, Ali A.
N1 - Funding Information:
From the Edward Mallinckrodt Institute of Radiology and the Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri. This study was supported in part by grant HLl7646 [Specialized Centers of Research in Ischemic Heart Disease) and grant ROl HL25430-OlAl from the National Institutes of Health, Bethesda, Maryland. Manuscript received February 21, 1986; revised manuscript received April 3, 1986, accepted April 4, 1986. Address for reprints: Tom R. Miller, MD, PhD, Edward Mal-linckrodt Institute of Radiology, 510 South Kingshighway Boulevard, St. Louis, Missouri 63110.
PY - 1986/9/1
Y1 - 1986/9/1
N2 - Thirty normal subjects, aged 22 to 80 years, were studied by radionuclide ventriculography to determine the age dependence of cardiac ventricular diastolic function and to evaluate the association of other factors with ventricular diastolic performance. A strong negative correlation was found between peak diastolic filling rate and age (r = -0.82, p < 0.0001). Partial correlation analysis was used to factor out the strong age dependence and yielded additional significant correlations of peak filling rate with heart rate (r = 0.48, p < 0.01) and time to peak filling rate (r = -0.48, p < 0.01). Time to peak filling rate is also correlated with heart rate but not definitely with age. Analysis by multiple linear regression yields an equation predicting peak filling rate from age and heart rate. Thus, the rate of rapid diastolic filling declines markedly with age in normal subjects. The association of peak filling rate with age and with other factors indicates the need for careful consideration of these factors in the interpretation of scintigraphic findings in patients with heart disease.
AB - Thirty normal subjects, aged 22 to 80 years, were studied by radionuclide ventriculography to determine the age dependence of cardiac ventricular diastolic function and to evaluate the association of other factors with ventricular diastolic performance. A strong negative correlation was found between peak diastolic filling rate and age (r = -0.82, p < 0.0001). Partial correlation analysis was used to factor out the strong age dependence and yielded additional significant correlations of peak filling rate with heart rate (r = 0.48, p < 0.01) and time to peak filling rate (r = -0.48, p < 0.01). Time to peak filling rate is also correlated with heart rate but not definitely with age. Analysis by multiple linear regression yields an equation predicting peak filling rate from age and heart rate. Thus, the rate of rapid diastolic filling declines markedly with age in normal subjects. The association of peak filling rate with age and with other factors indicates the need for careful consideration of these factors in the interpretation of scintigraphic findings in patients with heart disease.
UR - http://www.scopus.com/inward/record.url?scp=0022535393&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(86)90028-7
DO - 10.1016/0002-9149(86)90028-7
M3 - Article
C2 - 3751916
AN - SCOPUS:0022535393
SN - 0002-9149
VL - 58
SP - 531
EP - 535
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 6
ER -