TY - JOUR
T1 - Left ventricular diastolic filling abnormalities in left anterior descending disease
AU - Lavine, Steven J.
AU - Dennenberg, Barry S.
AU - Bove, A. Alfred
AU - Spann, J. F.
PY - 1987/1/1
Y1 - 1987/1/1
N2 - Reduced left ventricular diastolic filling (Df) has been noted in coronary disease (CD) patients with normal left ventricular systolic function (NLVF). However, previous studies have included patients with regional wall disease, hypertension, or left ventricular hypertrophy. In the absence of these factors, only a subgroup of patients who had >75% luminal obstruction of the left anterior descending artery (LAD) demonstrated DF abnormalities. Using 60 frames/sec biplane contrast ventriculography, we evaluated the left ventricular filling curve and its derivative in 21 patients with normal coronary arteries and NLVF (group 1), 17 CD patients with NLVF and no LAD disease (group 2), and 18 patients with LAD disease and NLVF (group 3). The peak filling rate (PFR) as end diastolic volumes/sec (EDV/S) was reduced in group 3 patients (group 3: 3.00 ± 0.51 EDV/S vs group 1: 3.59 ± 0.84 EDV/S, p <.05; and group 2: 3.61 ± 0.91 EDV/S, p <.05). There was marked overlap in the Pfr's between the normal and LAD group. DF may be normal in CD patients with NLVF in the absence of LAD disease. LAD patients have abnormal DF, but these abnormalities lack predictive valve.
AB - Reduced left ventricular diastolic filling (Df) has been noted in coronary disease (CD) patients with normal left ventricular systolic function (NLVF). However, previous studies have included patients with regional wall disease, hypertension, or left ventricular hypertrophy. In the absence of these factors, only a subgroup of patients who had >75% luminal obstruction of the left anterior descending artery (LAD) demonstrated DF abnormalities. Using 60 frames/sec biplane contrast ventriculography, we evaluated the left ventricular filling curve and its derivative in 21 patients with normal coronary arteries and NLVF (group 1), 17 CD patients with NLVF and no LAD disease (group 2), and 18 patients with LAD disease and NLVF (group 3). The peak filling rate (PFR) as end diastolic volumes/sec (EDV/S) was reduced in group 3 patients (group 3: 3.00 ± 0.51 EDV/S vs group 1: 3.59 ± 0.84 EDV/S, p <.05; and group 2: 3.61 ± 0.91 EDV/S, p <.05). There was marked overlap in the Pfr's between the normal and LAD group. DF may be normal in CD patients with NLVF in the absence of LAD disease. LAD patients have abnormal DF, but these abnormalities lack predictive valve.
KW - coronary artery disease
KW - diastolic function
UR - http://www.scopus.com/inward/record.url?scp=0023178256&partnerID=8YFLogxK
U2 - 10.1002/ccd.1810130405
DO - 10.1002/ccd.1810130405
M3 - Article
C2 - 3621337
AN - SCOPUS:0023178256
VL - 13
SP - 245
EP - 252
JO - Catheterization and Cardiovascular Diagnosis
JF - Catheterization and Cardiovascular Diagnosis
SN - 0098-6569
IS - 4
ER -