Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study

Stephen C. Gradwohl; Amrita Aranake; Arbi Ben Abdallah; Paul McNair; Nan Lin; Bradley A. Fritz; Alex Villafranca; David Glick; Eric Jacobsohn; George A. Mashour; Michael S. Avidan

doi:10.1007/s12630-014-0305-8

Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study

Translated title of the contribution: Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study

Stephen C. Gradwohl
, Amrita Aranake
, Arbi Ben Abdallah
, Paul McNair
, Nan Lin
, Bradley A. Fritz
, Alex Villafranca
, David Glick
, Eric Jacobsohn
, George A. Mashour
, Michael S. Avidan

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Purpose: The red-hair phenotype, which is often produced by mutations in the melanocortin-1 receptor gene, has been associated with an increase in sedative, anesthetic, and analgesic requirements in both animal and human studies. Nevertheless, the clinical implications of this phenomenon in red-haired patients undergoing surgery are currently unknown.

Translated title of the contribution	Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study
Original language	English
Pages (from-to)	345-355
Number of pages	11
Journal	Canadian Journal of Anesthesia
Volume	62
Issue number	4
DOIs	https://doi.org/10.1007/s12630-014-0305-8
State	Published - Apr 2015

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Gradwohl, S. C., Aranake, A., Abdallah, A. B., McNair, P., Lin, N., Fritz, B. A., Villafranca, A., Glick, D., Jacobsohn, E., Mashour, G. A., & Avidan, M. S. (2015). Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study. Canadian Journal of Anesthesia, 62(4), 345-355. https://doi.org/10.1007/s12630-014-0305-8

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title = "Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study",

abstract = "Purpose: The red-hair phenotype, which is often produced by mutations in the melanocortin-1 receptor gene, has been associated with an increase in sedative, anesthetic, and analgesic requirements in both animal and human studies. Nevertheless, the clinical implications of this phenomenon in red-haired patients undergoing surgery are currently unknown.",

author = "Gradwohl, \{Stephen C.\} and Amrita Aranake and Abdallah, \{Arbi Ben\} and Paul McNair and Nan Lin and Fritz, \{Bradley A.\} and Alex Villafranca and David Glick and Eric Jacobsohn and Mashour, \{George A.\} and Avidan, \{Michael S.\}",

note = "Publisher Copyright: {\textcopyright} 2015, Canadian Anesthesiologists' Society.",

year = "2015",

month = apr,

doi = "10.1007/s12630-014-0305-8",

language = "English",

volume = "62",

pages = "345--355",

journal = "Canadian Journal of Anesthesia",

issn = "0832-610X",

number = "4",

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Gradwohl, SC, Aranake, A, Abdallah, AB, McNair, P, Lin, N, Fritz, BA, Villafranca, A, Glick, D, Jacobsohn, E, Mashour, GA & Avidan, MS 2015, 'Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study', Canadian Journal of Anesthesia, vol. 62, no. 4, pp. 345-355. https://doi.org/10.1007/s12630-014-0305-8

TY - JOUR

T1 - Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair

T2 - a matched cohort study

AU - Gradwohl, Stephen C.

AU - Aranake, Amrita

AU - Abdallah, Arbi Ben

AU - McNair, Paul

AU - Lin, Nan

AU - Fritz, Bradley A.

AU - Villafranca, Alex

AU - Glick, David

AU - Jacobsohn, Eric

AU - Mashour, George A.

AU - Avidan, Michael S.

PY - 2015/4

Y1 - 2015/4

N2 - Purpose: The red-hair phenotype, which is often produced by mutations in the melanocortin-1 receptor gene, has been associated with an increase in sedative, anesthetic, and analgesic requirements in both animal and human studies. Nevertheless, the clinical implications of this phenomenon in red-haired patients undergoing surgery are currently unknown.

AB - Purpose: The red-hair phenotype, which is often produced by mutations in the melanocortin-1 receptor gene, has been associated with an increase in sedative, anesthetic, and analgesic requirements in both animal and human studies. Nevertheless, the clinical implications of this phenomenon in red-haired patients undergoing surgery are currently unknown.

UR - https://www.scopus.com/pages/publications/84925481622

U2 - 10.1007/s12630-014-0305-8

DO - 10.1007/s12630-014-0305-8

M3 - Article

C2 - 25681040

AN - SCOPUS:84925481622

SN - 0832-610X

VL - 62

SP - 345

EP - 355

JO - Canadian Journal of Anesthesia

JF - Canadian Journal of Anesthesia

IS - 4

ER -

Intraoperative awareness risk, anesthetic sensitivity, and anesthetic management for patients with natural red hair: a matched cohort study

Abstract

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