TY - JOUR
T1 - Launching Effectiveness Research to Guide Practice in Neurosurgery
T2 - A National Institute Neurological Disorders and Stroke Workshop Report
AU - Workshop Participants
AU - Walicke, Patricia
AU - Abosch, Aviva
AU - Asher, Anthony
AU - Barker, Fred G.
AU - Ghogawala, Zoher
AU - Harbaugh, Robert
AU - Jehi, Lara
AU - Kestle, John
AU - Koroshetz, Walter
AU - Little, Roderick
AU - Rubin, Donald
AU - Valadka, Alex
AU - Wisniewski, Stephen
AU - Chiocca, E. Antonio
AU - Amin-Hanjani, Sepideh
AU - Barbaro, Nicholas
AU - Berger, Mitchell
AU - Berliner, Elise
AU - Blumenkopf, Bennett
AU - Brown, Robert D.
AU - Bydon, Mohammed
AU - Califf, Robert
AU - Chang, Eddie
AU - Chimowitz, Marc
AU - Connolly, Sander
AU - Dacey, Ralph
AU - Frangakis, Constantine
AU - Friedlander, Robert
AU - Fureman, Brandy
AU - Gutman, Roee
AU - Holloway, Robert
AU - Kim, Scott
AU - Kondziolka, Douglas
AU - Lonser, Russell
AU - Manley, Geoff
AU - Ojemann, Jeffrey
AU - Pena, Carlos
AU - Platt, Richard
AU - Sampson, John
AU - Schafer, Jyme
AU - Tosteson, Tor D.
AU - Vickrey, Barbara
AU - Warf, Benjamin
N1 - Publisher Copyright:
Copyright © 2017 by the Congress of Neurological Surgeons.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice.Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."
AB - This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice.Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."
KW - Clinical trials
KW - Effectiveness research
KW - Equipoise
KW - Randomized controlled trial
KW - Registry
UR - http://www.scopus.com/inward/record.url?scp=85021644076&partnerID=8YFLogxK
U2 - 10.1093/neuros/nyw133
DO - 10.1093/neuros/nyw133
M3 - Article
C2 - 28362926
AN - SCOPUS:85021644076
SN - 0069-4827
VL - 80
SP - 505
EP - 514
JO - Clinical Neurosurgery
JF - Clinical Neurosurgery
IS - 4
ER -