Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report

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23 Scopus citations

Abstract

This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice.Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."

Original languageEnglish
Pages (from-to)505-514
Number of pages10
JournalClinical Neurosurgery
Volume80
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Clinical trials
  • Effectiveness research
  • Equipoise
  • Randomized controlled trial
  • Registry

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