Lateral diffusion in planar lipid bilayers

P. F. Fahey, D. E. Koppel, L. S. Barak, D. E. Wolf, E. L. Elson, W. W. Webb

Research output: Contribution to journalArticle

183 Scopus citations

Abstract

Direct measurements by fluorescence correlation spectroscopy of lateral diffusion coefficients of fluorescent lipid analogs in lipid bilayer membranes indicate self-diffusion coefficients D ≳ 10-7 square centimeters per second for various lipid systems above their reported transition temperatures. Cholesterol in egg lecithin at mole ratio of 1 : 2 reduces D by about twofold, while retained hydrocarbon solvent can increase it by two- to threefold.

Original languageEnglish
Pages (from-to)305-306
Number of pages2
JournalScience
Volume195
Issue number4275
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

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    Fahey, P. F., Koppel, D. E., Barak, L. S., Wolf, D. E., Elson, E. L., & Webb, W. W. (1977). Lateral diffusion in planar lipid bilayers. Science, 195(4275), 305-306. https://doi.org/10.1126/science.831279