TY - JOUR
T1 - Latent structure of cognitive performance in the adult children study
AU - Head, Denise
AU - Allison, Samantha
AU - Lucena, Nathaniel
AU - Hassenstab, Jason
AU - Morris, John C.
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/8/9
Y1 - 2017/8/9
N2 - Objective: The Adult Children Study (ACS) at the Knight Alzheimer’s Disease Research Center is a longitudinal investigation designed to identify and validate potential biomarkers of preclinical Alzheimer’s disease (AD) in cognitively normal individuals with and without a family history of AD. The purpose of the current study was to validate the proposed latent structure of the ACS psychometric battery. Method: Confirmatory factor analyses of baseline data in a sample of 229 (75 men) cognitively normal middle-aged to older adult individuals assessed a hypothesized 4-factor model of cognitive performance. Measurement invariance was investigated as a function of family history of AD and apolipoprotein E (APOE) status. Results: This study confirmed a priori hypotheses of 4 latent cognitive domains in a unique longitudinal sample of cognitively normal adults. In addition, there was evidence of a similar factor structure for family history and APOE status groups. Conclusion: These robust indicators of a broad range of cognitive domains will be used in future investigations to track the influence of family history of AD on cognitive performance over time. In addition, associations with fluid, structural, and molecular biomarkers of preclinical AD will be further examined, both cross-sectionally and longitudinally in this sample.
AB - Objective: The Adult Children Study (ACS) at the Knight Alzheimer’s Disease Research Center is a longitudinal investigation designed to identify and validate potential biomarkers of preclinical Alzheimer’s disease (AD) in cognitively normal individuals with and without a family history of AD. The purpose of the current study was to validate the proposed latent structure of the ACS psychometric battery. Method: Confirmatory factor analyses of baseline data in a sample of 229 (75 men) cognitively normal middle-aged to older adult individuals assessed a hypothesized 4-factor model of cognitive performance. Measurement invariance was investigated as a function of family history of AD and apolipoprotein E (APOE) status. Results: This study confirmed a priori hypotheses of 4 latent cognitive domains in a unique longitudinal sample of cognitively normal adults. In addition, there was evidence of a similar factor structure for family history and APOE status groups. Conclusion: These robust indicators of a broad range of cognitive domains will be used in future investigations to track the influence of family history of AD on cognitive performance over time. In addition, associations with fluid, structural, and molecular biomarkers of preclinical AD will be further examined, both cross-sectionally and longitudinally in this sample.
KW - Cognitive aging
KW - Confirmatory factor analysis
KW - Measurement invariance
KW - Psychometric test battery
UR - http://www.scopus.com/inward/record.url?scp=84995549378&partnerID=8YFLogxK
U2 - 10.1080/13803395.2016.1252725
DO - 10.1080/13803395.2016.1252725
M3 - Article
C2 - 27868476
AN - SCOPUS:84995549378
SN - 1380-3395
VL - 39
SP - 621
EP - 635
JO - Journal of Clinical and Experimental Neuropsychology
JF - Journal of Clinical and Experimental Neuropsychology
IS - 7
ER -