Latent gammaherpesvirus 68 infection induces distinct transcriptional changes in different organs

Susan P. Canny, Gautam Goel, Tiffany A. Reese, Xin Zhang, Ramnik Xavier, Herbert W. Virgin

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Previous studies identified a role for latent herpesvirus infection in cross-protection against infection and exacerbation of chronic inflammatory diseases. Here, we identified more than 500 genes differentially expressed in spleens, livers, or brains of mice latently infected with gammaherpesvirus 68 and found that distinct sets of genes linked to different pathways were altered in the spleen compared to those in the liver. Several of the most differentially expressed latency-specific genes (e.g., the gamma interferon [IFN-γ], Cxcl9, and Ccl5 genes) are associated with known latency-specific phenotypes. Chronic herpesvirus infection, therefore, significantly alters the transcriptional status of host organs. We speculate that such changes may influence host physiology, the status of the immune system, and disease susceptibility.

Original languageEnglish
Pages (from-to)730-738
Number of pages9
JournalJournal of virology
Volume88
Issue number1
DOIs
StatePublished - Jan 1 2014

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    Canny, S. P., Goel, G., Reese, T. A., Zhang, X., Xavier, R., & Virgin, H. W. (2014). Latent gammaherpesvirus 68 infection induces distinct transcriptional changes in different organs. Journal of virology, 88(1), 730-738. https://doi.org/10.1128/JVI.02708-13