Late injury of cancer therapy on the female reproductive tract

Perry W. Grigsby, Anthony Russell, Deborah Bruner, Patricia Eifel, Wui Jin Koh, William Spanos, Joann Stetz, Judith Anne Stitt, Jessie Sullivan

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


The purpose of this article is to review the late effects of cancer therapy on the female reproductive tract. The anatomic sites detailed are the vulva, vagina, cervix, uterus, fallopian tubes, and ovaries. The available pathophysiology is discussed. Clinical syndromes are presented. Tolerance doses of irradiation for late effects are rarely presented in the literature and are reviewed where available. Management strategies for surgical, radiotherapeutic, and chemotherapeutic late effects are discussed. Endpoints for evaluation of therapeutic late effects have been formulated utilizing the symptons, objective, management, and analytic (SOMA) format. Late effects on the female reproductive tract from cancer therapy should be recognized and managed appropriately. A grading system for these effects is presented. Endpoints for late effects and tolls for the evaluation need to be further developed.

Original languageEnglish
Pages (from-to)1281-1299
Number of pages19
JournalInternational journal of radiation oncology, biology, physics
Issue number5
StatePublished - Mar 30 1995


  • Cervix
  • Chemotherapy
  • Fallopian tube
  • Female reproductive tract
  • Late effects
  • Ovary
  • Radiation
  • Surgery
  • Uterus
  • Vagina
  • Vulva


Dive into the research topics of 'Late injury of cancer therapy on the female reproductive tract'. Together they form a unique fingerprint.

Cite this