Late bleb-related endophthalmitis after trabeculectomy with mitomycin C

Y. A. Akova, S. Bulut, H. Dabil, S. Duman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


To present two cases of delayed-onset post-operative endophthalmitis following trabeculectomy combined with mitomycin C for secondary glaucoma after penetrating keratoplasty. We retrospectively evaluated two patients with late endophthalmitis after trabeculectomy combined with intraoperative mitomycin C application. Both patients underwent trabeculectomy for uncontrolled glaucoma following penetrating keratoplasty and they developed thin-walled cystic blebs. Intraocular pressure was normal, and grafts remained clear postoperatively. Severe endophthalmitis with hypopyon developed at 3 and 7 months postoperatively. Both patients had concomitant bleb infection. They underwent vitreous sampling and intravitreal injection of vancomycin and amikacin and were given topical fortified and systemic antibiotic therapy. Intravitreal injection was repeated once in both patients. Cultures grew Streptococcus pneumonias in one and Staphylococcus aureus in the other. Although the treatment of endophthalmitis was successful in both patients, only one of them achieved useful vision (20/40). For the other patient who had been infected with S. pneumoniae, vision was light perception. Delayed-onset endophthalmitis following trabeculectomy with mitomycin C application is as severe and vision threatening complication. It seems that the development of thin cystic filtering blebs secondary to intraoperative mitomycin C application may be a predisposing factor for bleb- related late endophthalmitis.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalOphthalmic Surgery and Lasers
Issue number2
StatePublished - Feb 1 1999


Dive into the research topics of 'Late bleb-related endophthalmitis after trabeculectomy with mitomycin C'. Together they form a unique fingerprint.

Cite this