Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: An animal model

Benjamin S. Bleier, Michael A. Gratton, Jason M. Leibowitz, James N. Palmer, Jason G. Newman, Noam A. Cohen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: To test the feasibility of laser tissue welding (LTW) in creating an endoscopic transluminal repair of esophageal perforation. Study Design: Animal model. Subjects and Methods: A diode laser was used to create an endoluminal rabbit esophageal perforation repair. Burst pressures were compared with open incision, external suture, and external laser-augmented suture closure. Comparisons were performed five times and analyzed with Kruskal-Wallis analysis of variance and a post hoc Dunn method. Results: The burst threshold of the endoluminal weld (54.78 ± 5.84 mm Hg) was significantly higher than that of the open incision (6.5 ± 1.94 mm Hg) and not significantly different than that of the external suture (37.18 ± 1.97 mm Hg) or the laser-augmented suture group (71.60 ± 7.58 mm Hg). Conclusion: Laser welding is a feasible method of creating endoluminal repairs with burst strengths comparable with external suture repair, which may allow a subset of patients to avoid traditional open approaches. This is the first reported animal model of LTW for endoscopic closure of iatrogenic esophageal perforation.

Original languageEnglish
Pages (from-to)713-717
Number of pages5
JournalOtolaryngology - Head and Neck Surgery
Issue number5
StatePublished - Nov 2008


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