Laser stimulation of the skin for quantitative study of decision-making and motivation

Julia Pai, Takaya Ogasawara, Ethan S. Bromberg-Martin, Kei Ogasawara, Robert W. Gereau, Ilya E. Monosov

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Neuroeconomics studies how decision-making is guided by the value of rewards and punishments. But to date, little is known about how noxious experiences impact decisions. A challenge is the lack of an aversive stimulus that is dynamically adjustable in intensity and location, readily usable over many trials in a single experimental session, and compatible with multiple ways to measure neuronal activity. We show that skin laser stimulation used in human studies of aversion can be used for this purpose in several key animal models. We then use laser stimulation to study how neurons in the orbitofrontal cortex (OFC), an area whose many roles include guiding decisions among different rewards, encode the value of rewards and punishments. We show that some OFC neurons integrated the positive value of rewards with the negative value of aversive laser stimulation, suggesting that the OFC can play a role in more complex choices than previously appreciated.

Original languageEnglish
Article number100296
JournalCell Reports Methods
Issue number9
StatePublished - Sep 19 2022


  • aversion
  • decision
  • motivation
  • neuroeconomics
  • orbitofrontal
  • value


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