Laser Interstitial Thermal Therapy in Grade 2/3 IDH1/2 Mutant Gliomas: A Preliminary Report and Literature Review

Gabrielle W. Johnson, Rowland H. Han, Matthew D. Smyth, Eric C. Leuthardt, Albert H. Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Laser interstitial thermal therapy (LITT) has become an increasingly utilized alternative to surgical resection for the treatment of glioma in patients. However, treatment outcomes in isocitrate dehydrogenase 1 and 2 (IDH1/2) mutant glioma, specifically, have not been reported. The objective of this study was to characterize a single institution’s cohort of IDH1/2 mutant grade 2/3 glioma patients treated with LITT. We collected data on patient presentation, radiographic features, tumor molecular profile, complications, and outcomes. We calculated progression-free survival (PFS) and tested factors for significant association with longer PFS. Overall, 22.7% of our cohort experienced progression at a median follow up of 1.8 years. The three-and five-year estimates of PFS were 72.5% and 54.4%, respectively. This is the first study to characterize outcomes in patients with IDH1/2 mutant glioma after LITT. Our results suggest that LITT is an effective treatment option for IDH1/2 mutant glioma.

Original languageEnglish
Pages (from-to)2550-2563
Number of pages14
JournalCurrent Oncology
Volume29
Issue number4
DOIs
StatePublished - Apr 2022

Keywords

  • IDH1 mutation
  • IDH2 mutation
  • astrocytoma
  • glioma
  • laser interstitial thermal therapy
  • oligodendroglioma

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