TY - JOUR
T1 - Laser interstitial thermal therapy for new and recurrent meningioma
T2 - a prospective and retrospective case series
AU - Chiang, Veronica L.
AU - Pugazenthi, Sangami
AU - Leidig, William A.
AU - Rodriguez, Analiz
AU - Prabhu, Sujit
AU - Haskell-Mendoza, Aden P.
AU - Fecci, Peter E.
AU - Placantonakis, Dimitris G.
AU - Abram, Steven R.
AU - Lega, Bradley
AU - Kim, Albert H.
N1 - Publisher Copyright:
© 2024 The authors.
PY - 2024/9
Y1 - 2024/9
N2 - OBJECTIVE Meningiomas are the most common primary brain tumors in adults and a subset are aggressive lesions resistant to standard therapies. Laser interstitial thermal therapy (LITT) has been successfully applied to other brain tumors, and recent work aims to explore the safety and long-term outcome experiences of LITT for both new and recurrent meningiomas. The authors' objective was to report safety and outcomes data of the largest cohort of LITT-treated meningioma patients to date. METHODS Eight United States-based hospitals enrolled patients with meningioma in the Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN) prospective multicenter registry and/or contributed additional retrospective enrollments for this cohort study. Demographic, procedural, safety, and outcomes data were collected and analyzed using standard statistical methods. RESULTS Twenty adult patients (12 prospective and 8 retrospective) with LITT-targeted meningiomas were accrued. Patients underwent LITT for new (6 patients) and recurrent (14 patients) tumors (ranging from the 1st to 12th recurrence). The 30-day complication rate was 10%. Twenty percent of patients (4/20) had exhausted all other treatment options. Median length of follow-up was 1.3 years. One-third of new (2/6) and one-half of recurrent (7/14) meningiomas had disease progression during follow-up. One-year estimated local control (LC), progression-free survival, and overall survival rates were 55.3%, 48.4%, and 86.3%, respectively. In the 12 patients who had ≥ 91% ablative coverage, 1-year estimated LC was 61.4%. The complication rate was 10% (2/20), with 1 complication being transient and resolving postoperatively. CONCLUSIONS This cohort study supports the safety of the procedure for this tumor type. LITT can offer a muchneeded treatment option, especially for patients with multiply recurrent meningiomas who have limited remaining alternatives.
AB - OBJECTIVE Meningiomas are the most common primary brain tumors in adults and a subset are aggressive lesions resistant to standard therapies. Laser interstitial thermal therapy (LITT) has been successfully applied to other brain tumors, and recent work aims to explore the safety and long-term outcome experiences of LITT for both new and recurrent meningiomas. The authors' objective was to report safety and outcomes data of the largest cohort of LITT-treated meningioma patients to date. METHODS Eight United States-based hospitals enrolled patients with meningioma in the Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN) prospective multicenter registry and/or contributed additional retrospective enrollments for this cohort study. Demographic, procedural, safety, and outcomes data were collected and analyzed using standard statistical methods. RESULTS Twenty adult patients (12 prospective and 8 retrospective) with LITT-targeted meningiomas were accrued. Patients underwent LITT for new (6 patients) and recurrent (14 patients) tumors (ranging from the 1st to 12th recurrence). The 30-day complication rate was 10%. Twenty percent of patients (4/20) had exhausted all other treatment options. Median length of follow-up was 1.3 years. One-third of new (2/6) and one-half of recurrent (7/14) meningiomas had disease progression during follow-up. One-year estimated local control (LC), progression-free survival, and overall survival rates were 55.3%, 48.4%, and 86.3%, respectively. In the 12 patients who had ≥ 91% ablative coverage, 1-year estimated LC was 61.4%. The complication rate was 10% (2/20), with 1 complication being transient and resolving postoperatively. CONCLUSIONS This cohort study supports the safety of the procedure for this tumor type. LITT can offer a muchneeded treatment option, especially for patients with multiply recurrent meningiomas who have limited remaining alternatives.
KW - brain tumor
KW - laser interstitial thermal therapy
KW - meningioma
KW - stereotactic laser ablation
UR - http://www.scopus.com/inward/record.url?scp=85200908045&partnerID=8YFLogxK
U2 - 10.3171/2023.12.JNS231542
DO - 10.3171/2023.12.JNS231542
M3 - Article
C2 - 38457795
AN - SCOPUS:85200908045
SN - 0022-3085
VL - 141
SP - 642
EP - 652
JO - Journal of neurosurgery
JF - Journal of neurosurgery
IS - 3
ER -