@inproceedings{6182be482aa244c380e41005885b10f0,
title = "Laser-Engineered Fiber for Reconfigurable Control of Neural Activity",
abstract = "We present a laser-engineered fiber-optic implant capable of emitting light from over 1,000 independent sites within a single fiber. By selectively launching light into specific channels, the emission patterns can be dynamically reconfigured, enabling versatile light delivery with a single fiber implant. To demonstrate its efficacy, distinct defensive behaviors were evoked in freely moving mice by targeting different depths of the superior colliculus. This reconfigurable light delivery across large tissue volumes opens new possibilities for massively parallel causal investigation of neural activities across brain regions through optical manipulation.",
keywords = "fiber optics, laser micromachining, optogenetics",
author = "Shuo Yang and Keran Yang and Quentin Chevy and Adam Kepecs and Song Hu",
note = "Publisher Copyright: {\textcopyright} 2025 SPIE.; Optogenetics and Optical Manipulation 2025 ; Conference date: 25-01-2025 Through 26-01-2025",
year = "2025",
doi = "10.1117/12.3042545",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Roe, {Anna Wang} and Shy Shoham",
booktitle = "Optogenetics and Optical Manipulation 2025",
}