TY - JOUR
T1 - Laryngeal reinnervation
AU - Paniello, Randal C.
N1 - Funding Information:
We have initiated a multicenter, prospective, randomized clinical trial to address this question. Twelve participating medical centers will invite patients with previously untreated UVFP to enter the study. Acoustic, aerodynamic, EMG, and clinical outcomes data will be collected before surgery and at 6 and 12 months after surgery. This 5-year study is being supported by a grant from the National Institutes of Health–NIDCD.
PY - 2004/2
Y1 - 2004/2
N2 - Laryngeal reinnervation refers to any of a number of surgical procedures intended to restore neural connections to the larynx, which have usually been lost from some type of trauma (eg, surgical). The nerve function(s) to be restored may be those of the recurrent laryngeal nerve or its subdivisions, those of the superior laryngeal nerve, or both, and they may be motor or sensory. Several different donor nerves are available and have been described. The technique used may be direct end-to-end anastomosis (neurorrhaphy), direct implantation of a nerve ending into a muscle, the nerve-muscle pedicle technique, or muscle-nerve-muscle methods. These nerves and techniques may be combined in many ways. A number of new techniques have been reported in animal studies; however, the animal studies do not always predict the results of analogous surgeries in human patients. The historical and current perspectives on these techniques are discussed in this article.
AB - Laryngeal reinnervation refers to any of a number of surgical procedures intended to restore neural connections to the larynx, which have usually been lost from some type of trauma (eg, surgical). The nerve function(s) to be restored may be those of the recurrent laryngeal nerve or its subdivisions, those of the superior laryngeal nerve, or both, and they may be motor or sensory. Several different donor nerves are available and have been described. The technique used may be direct end-to-end anastomosis (neurorrhaphy), direct implantation of a nerve ending into a muscle, the nerve-muscle pedicle technique, or muscle-nerve-muscle methods. These nerves and techniques may be combined in many ways. A number of new techniques have been reported in animal studies; however, the animal studies do not always predict the results of analogous surgeries in human patients. The historical and current perspectives on these techniques are discussed in this article.
UR - http://www.scopus.com/inward/record.url?scp=1542286181&partnerID=8YFLogxK
U2 - 10.1016/S0030-6665(03)00164-6
DO - 10.1016/S0030-6665(03)00164-6
M3 - Review article
C2 - 15062692
AN - SCOPUS:1542286181
SN - 0030-6665
VL - 37
SP - 161
EP - 181
JO - Otolaryngologic Clinics of North America
JF - Otolaryngologic Clinics of North America
IS - 1
ER -