Large Vessel Arteriopathy After Cranial Radiation Therapy in Pediatric Brain Tumor Survivors

Matthew Nordstrom, Erin Felton, Katherine Sear, Benita Tamrazi, Joseph Torkildson, Karen Gauvain, Daphne A. Haas-Kogan, Josephine Chen, Benedict Del Buono, Anuradha Banerjee, David Samuel, David Saloner, Bing Tian, Erika Roddy, Christopher Hess, Heather Fullerton, Sabine Mueller

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Among childhood cancer survivors, increased stroke risk after cranial radiation therapy may be caused by radiation-induced arteriopathy, but limited data exist to support this hypothesis. Herein, we assess the timing and presence of cerebral arteriopathy identified by magnetic resonance angiography (MRA) after cranial radiation therapy in childhood brain tumor survivors. In a cohort of 115 pediatric brain tumor survivors, we performed chart abstraction and prospective annual follow-up to assess the presence of large vessel cerebral arteriopathy by MRA. We identified 10 patients with cerebral arteriopathy. The cumulative incidence of arteriopathy 5 years post–cranial radiation therapy was 5.4% (CI 0.6%-10%) and 10 years was 16% (CI 4.6%-26%). One patient had an arterial ischemic stroke 2.4 years post–cranial radiation therapy in the distribution of a radiation-induced stenotic artery. We conclude that large vessel arteriopathies can occur within a few years of cranial radiation therapy and can become apparent on MRA in under a year.

Original languageEnglish
Pages (from-to)359-366
Number of pages8
JournalJournal of Child Neurology
Volume33
Issue number5
DOIs
StatePublished - Apr 1 2018

Keywords

  • MRI
  • brain tumor
  • neurooncology
  • pediatric
  • stroke

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    Nordstrom, M., Felton, E., Sear, K., Tamrazi, B., Torkildson, J., Gauvain, K., Haas-Kogan, D. A., Chen, J., Buono, B. D., Banerjee, A., Samuel, D., Saloner, D., Tian, B., Roddy, E., Hess, C., Fullerton, H., & Mueller, S. (2018). Large Vessel Arteriopathy After Cranial Radiation Therapy in Pediatric Brain Tumor Survivors. Journal of Child Neurology, 33(5), 359-366. https://doi.org/10.1177/0883073818756729