Large deviations in the distribution of rare genes

D. C. Rao, N. E. Morton

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A gene rare in a species is sometimes found to have an appreciable frequency in a restricted population, suggesting either genetic drift, founder effect, or local selective advantage. Here the authors show that large deviations from the mean gene frequency are not improbable and they could very well occur due to chance alone. Methodology is illustrated for Tay Sachs disease and cystic fibrosis.

Original languageEnglish
Pages (from-to)594-597
Number of pages4
JournalAmerican journal of human genetics
Volume25
Issue number6
StatePublished - 1973

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