A gene rare in a species is sometimes found to have an appreciable frequency in a restricted population, suggesting either genetic drift, founder effect, or local selective advantage. Here the authors show that large deviations from the mean gene frequency are not improbable and they could very well occur due to chance alone. Methodology is illustrated for Tay Sachs disease and cystic fibrosis.
|Number of pages||4|
|Journal||American journal of human genetics|
|State||Published - 1973|