TY - JOUR
T1 - Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the alzheimer type
AU - Wang, Lei
AU - Beg, Faisal
AU - Ratnanather, Tilak
AU - Ceritpglu, Can
AU - Younes, Laurent
AU - Morris, John C.
AU - Csernansky, John G.
AU - Miller, Michael I.
N1 - Funding Information:
Manuscript received September 19, 2006; revised October 13, 2006. This work was supported in part by the National Institutes of Health (NIH) under Grant P50-MH71616, Grant R01-MH60883, Grant R01-MH56584, Grant R01-MH064838, Grant P01-AG03991, Grant R01-AG025824, and P50-AG05681, AG05684, in part by the National Center for Research Resources under Grant P41-RR15241, in part by the National Science Foundation under Grant DMS-0456253, in part by the Natural Sciences and Engineering Research Council (Canada) under Grant 31-611387, and in part by a grant from the HIGHQ Foundation (Canada). Asterisk indicates corresponding author. *L. Wang is with the Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S. Euclid Ave, St. Louis, MO 63110 USA (e-mail: [email protected]).
PY - 2007/4
Y1 - 2007/4
N2 - In large-deformation diffeomorphic metric mapping (LDDMM), the diffeomorphic matching of images are modeled as evolution in time, or a flow, of an associated smooth velocity vector field v controlling the evolution. The initial momentum parameterizes the whole geodesic and encodes the shape and form of the target image. Thus, methods such as principal component analysis (FCÄ) of the initial momentum leads to analysis of anatomical shape and form in target images without being restricted to smalldeformation assumption in the analysis of linear displacements. We apply this approach to a study of dementia of the Alzheimer type (DAT). The left hippocampus in the DAT group shows significant shape abnormality while the right hippocampus shows similar pattern of abnormality. Further, PCA of the initial momentum leads to correct classification of 12 out of 18 DAT subjects and 22 out of 26 control subjects.
AB - In large-deformation diffeomorphic metric mapping (LDDMM), the diffeomorphic matching of images are modeled as evolution in time, or a flow, of an associated smooth velocity vector field v controlling the evolution. The initial momentum parameterizes the whole geodesic and encodes the shape and form of the target image. Thus, methods such as principal component analysis (FCÄ) of the initial momentum leads to analysis of anatomical shape and form in target images without being restricted to smalldeformation assumption in the analysis of linear displacements. We apply this approach to a study of dementia of the Alzheimer type (DAT). The left hippocampus in the DAT group shows significant shape abnormality while the right hippocampus shows similar pattern of abnormality. Further, PCA of the initial momentum leads to correct classification of 12 out of 18 DAT subjects and 22 out of 26 control subjects.
KW - Alzheimer's disease
KW - Geodesic
KW - LDDMM
KW - Momentum
KW - PCA
UR - http://www.scopus.com/inward/record.url?scp=34047102407&partnerID=8YFLogxK
U2 - 10.1109/TMI.2006.887380
DO - 10.1109/TMI.2006.887380
M3 - Article
C2 - 17427733
AN - SCOPUS:34047102407
SN - 0278-0062
VL - 26
SP - 462
EP - 470
JO - IEEE Transactions on Medical Imaging
JF - IEEE Transactions on Medical Imaging
IS - 4
ER -