Laminin α5 guides tissue patterning and organogenesis

Caroline Spenlé, Patricia Simon-Assmann, Gertraud Orend, Jeffrey H. Miner

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5) is one of the most widely distributed LM in the developing and mature organism. Its presence in some basement membranes during embryogenesis is absolutely required for maintenance of basement membrane integrity and thus for proper organogenesis. LMα5 also regulates the expression of genes important for major biological processes, in part by repressing or activating signaling pathways, depending upon the physiological context.

Original languageEnglish
Pages (from-to)90-100
Number of pages11
JournalCell Adhesion and Migration
Issue number1
StatePublished - 2013


  • Basement membranes
  • Cell receptors
  • Extracellular matrix
  • Signaling pathways
  • Stem cells

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