TY - JOUR
T1 - Laminets
T2 - Laminin- and netrin-related genes expressed in distinct neuronal subsets
AU - Yin, Yong
AU - Miner, Jeffrey H.
AU - Sanes, Joshua R.
N1 - Funding Information:
We thank Renate Lewis for expert assistance with molecular biology and Joseph Price for advice on neuroanatomy. This work was supported by grants from the NIH to J.H.M and J.R.S.
PY - 2002
Y1 - 2002
N2 - Laminins and netrins are families of related secreted proteins known to play critical roles in guiding the growth of peripheral and central axons, respectively. Here we report the identification of two novel cell surface glycoproteins that we name laminets because they resemble both laminins and netrins. Laminet-1 and -2 are selectively expressed in neurons, each in a distinct subset that includes populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia. In several forebrain regions, including main relays of the central olfactory pathway, laminet-1 and -2 are expressed in nonoverlapping neuronal subsets. Both laminets are subject to alternative splicing which, in the case of laminet-1, generates at least 10 distinct isoforms, each of which contains a unique combination of potential binding sites for ligands or counterreceptors. Their complex patterns of distribution and isoform diversity, along with their homology to known axon guidance molecules, suggest that laminets contribute to the patterning of neuronal connections.
AB - Laminins and netrins are families of related secreted proteins known to play critical roles in guiding the growth of peripheral and central axons, respectively. Here we report the identification of two novel cell surface glycoproteins that we name laminets because they resemble both laminins and netrins. Laminet-1 and -2 are selectively expressed in neurons, each in a distinct subset that includes populations in forebrain, midbrain, hindbrain, spinal cord, and spinal ganglia. In several forebrain regions, including main relays of the central olfactory pathway, laminet-1 and -2 are expressed in nonoverlapping neuronal subsets. Both laminets are subject to alternative splicing which, in the case of laminet-1, generates at least 10 distinct isoforms, each of which contains a unique combination of potential binding sites for ligands or counterreceptors. Their complex patterns of distribution and isoform diversity, along with their homology to known axon guidance molecules, suggest that laminets contribute to the patterning of neuronal connections.
UR - http://www.scopus.com/inward/record.url?scp=0036215967&partnerID=8YFLogxK
U2 - 10.1006/mcne.2001.1089
DO - 10.1006/mcne.2001.1089
M3 - Article
C2 - 11906208
AN - SCOPUS:0036215967
SN - 1044-7431
VL - 19
SP - 344
EP - 358
JO - Molecular and Cellular Neuroscience
JF - Molecular and Cellular Neuroscience
IS - 3
ER -