Lag structure in resting-state fMRI

A. Mitra, A. Z. Snyder, C. D. Hacker, M. E. Raichle

Research output: Contribution to journalArticle

78 Scopus citations


The discovery that spontaneous fluctuations in blood oxygen level-dependent (BOLD) signals contain information about the functional organization of the brain has caused a paradigm shift in neuroimaging. It is now well established that intrinsic brain activity is organized into spatially segregated resting-state networks (RSNs). Less is known regarding how spatially segregated networks are integrated by the propagation of intrinsic activity over time. To explore this question, we examined the latency structure of spontaneous fluctuations in the fMRI BOLD signal. Our data reveal that intrinsic activity propagates through and across networks on a timescale of ~1 s. Variations in the latency structure of this activity resulting from sensory state manipulation (eyes open vs. closed), antecedent motor task (button press) performance, and time of day (morning vs. evening) suggest that BOLD signal lags reflect neuronal processes rather than hemodynamic delay. Our results emphasize the importance of the temporal structure of the brain's spontaneous activity.

Original languageEnglish
Pages (from-to)2374-2391
Number of pages18
JournalJournal of neurophysiology
Issue number11
StatePublished - Jun 1 2014


  • Dynamics
  • Functional connectivity
  • Resting state
  • fMRI

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