Lacosamide and Levetiracetam Are Not Toxic to the Developing Mouse Brain

Kevin K. Noguchi; Cory W. Palmer; Nicole A. Fuhler; Eric Neblock; Maya Fotedar; Chrysanthy Ikonomidou

doi:10.1002/ana.27052

Lacosamide and Levetiracetam Are Not Toxic to the Developing Mouse Brain

Kevin K. Noguchi, Cory W. Palmer, Nicole A. Fuhler, Eric Neblock, Maya Fotedar, Chrysanthy Ikonomidou

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Abstract

Many antiseizure medications cause apoptotic cell death in developing brains. The newer antiseizure medication lacosamide is increasingly used in neonates and infants. Neurotoxicity of lacosamide and its combination with levetiracetam was studied in neonatal mice. Animals received single or repeat injections of saline, phenobarbital (75mg/kg), lacosamide (20–40mg/kg), levetiracetam (100mg/kg), lacosamide (40mg/kg) + levetiracetam (100mg/kg) and euthanized at 6 to 30 hours. Cells undergoing apoptosis were increased in the brains of phenobarbital-treated animals. Densities of apoptotic profiles following lacosamide and levetiracetam treatment did not differ from saline-treated controls. Findings suggest that lacosamide, levetiracetam and their combination do not cause apoptosis in developing mouse brains. ANN NEUROL 2024;96:812–818.

Original language	English
Pages (from-to)	812-818
Number of pages	7
Journal	Annals of neurology
Volume	96
Issue number	4
DOIs	https://doi.org/10.1002/ana.27052
State	Published - Oct 2024

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title = "Lacosamide and Levetiracetam Are Not Toxic to the Developing Mouse Brain",

abstract = "Many antiseizure medications cause apoptotic cell death in developing brains. The newer antiseizure medication lacosamide is increasingly used in neonates and infants. Neurotoxicity of lacosamide and its combination with levetiracetam was studied in neonatal mice. Animals received single or repeat injections of saline, phenobarbital (75mg/kg), lacosamide (20–40mg/kg), levetiracetam (100mg/kg), lacosamide (40mg/kg) + levetiracetam (100mg/kg) and euthanized at 6 to 30 hours. Cells undergoing apoptosis were increased in the brains of phenobarbital-treated animals. Densities of apoptotic profiles following lacosamide and levetiracetam treatment did not differ from saline-treated controls. Findings suggest that lacosamide, levetiracetam and their combination do not cause apoptosis in developing mouse brains. ANN NEUROL 2024;96:812–818.",

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AU - Palmer, Cory W.

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AU - Fotedar, Maya

AU - Ikonomidou, Chrysanthy

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AB - Many antiseizure medications cause apoptotic cell death in developing brains. The newer antiseizure medication lacosamide is increasingly used in neonates and infants. Neurotoxicity of lacosamide and its combination with levetiracetam was studied in neonatal mice. Animals received single or repeat injections of saline, phenobarbital (75mg/kg), lacosamide (20–40mg/kg), levetiracetam (100mg/kg), lacosamide (40mg/kg) + levetiracetam (100mg/kg) and euthanized at 6 to 30 hours. Cells undergoing apoptosis were increased in the brains of phenobarbital-treated animals. Densities of apoptotic profiles following lacosamide and levetiracetam treatment did not differ from saline-treated controls. Findings suggest that lacosamide, levetiracetam and their combination do not cause apoptosis in developing mouse brains. ANN NEUROL 2024;96:812–818.

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Lacosamide and Levetiracetam Are Not Toxic to the Developing Mouse Brain

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