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Eosinophilic esophagitis (EoE) is an immune-mediated disorder characterized by esophageal inflammation and related structural changes causing symptoms such as feeding difficulties and food impaction. The pathophysiological mechanisms underlying EoE remain poorly understood. Preclinical studies using mouse models have been critical in comprehending human disease mechanisms and associated pathways. In this chapter, we describe an experimental method using a noninvasive label-free optical imaging technique, optical coherence tomography, to characterize the pathophysiological changes in the esophagus of mice with EoE-like disease ex vivo.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalMethods in Molecular Biology
StatePublished - 2016


  • EoE mouse models
  • Eosinophilic esophagitis
  • Gastrointestinal imaging
  • Label-free imaging
  • Optical coherence tomography
  • Optical imaging


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