TY - JOUR
T1 - Label-free imaging of eosinophilic esophagitis mouse models using optical coherence tomography
AU - Alex, Aneesh
AU - Tait Wojno, Elia D.
AU - Artis, David
AU - Zhou, Chao
N1 - Funding Information:
This work was supported by the Lehigh University Start-up Fund and the National Institute of Health/National Institute of Biomedical Imaging and Bioengineering (NIH/NIBIB) Pathway to Independence Award (R00EB010071 to C. Z.). Research in the Artis lab is supported by the US National Institutes of Health (AI061570, AI087990, AI074878, AI095776, AI102942, AI095466, AI095608, and AI097333 to D.A.), T32-AI060516 and F32-AI098365 to E.D.T.W., and the Burroughs Wellcome Fund Investigator in Pathogenesis of Infectious Disease Award to D.A.
Publisher Copyright:
© Springer Science+Business Media New York 2016.
PY - 2016
Y1 - 2016
N2 - Eosinophilic esophagitis (EoE) is an immune-mediated disorder characterized by esophageal inflammation and related structural changes causing symptoms such as feeding difficulties and food impaction. The pathophysiological mechanisms underlying EoE remain poorly understood. Preclinical studies using mouse models have been critical in comprehending human disease mechanisms and associated pathways. In this chapter, we describe an experimental method using a noninvasive label-free optical imaging technique, optical coherence tomography, to characterize the pathophysiological changes in the esophagus of mice with EoE-like disease ex vivo.
AB - Eosinophilic esophagitis (EoE) is an immune-mediated disorder characterized by esophageal inflammation and related structural changes causing symptoms such as feeding difficulties and food impaction. The pathophysiological mechanisms underlying EoE remain poorly understood. Preclinical studies using mouse models have been critical in comprehending human disease mechanisms and associated pathways. In this chapter, we describe an experimental method using a noninvasive label-free optical imaging technique, optical coherence tomography, to characterize the pathophysiological changes in the esophagus of mice with EoE-like disease ex vivo.
KW - EoE mouse models
KW - Eosinophilic esophagitis
KW - Gastrointestinal imaging
KW - Label-free imaging
KW - Optical coherence tomography
KW - Optical imaging
UR - http://www.scopus.com/inward/record.url?scp=84990055846&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-3603-8_12
DO - 10.1007/978-1-4939-3603-8_12
M3 - Article
C2 - 27246028
AN - SCOPUS:84990055846
SN - 1064-3745
VL - 1422
SP - 127
EP - 136
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -