KATP channels function as negative regulators of active lymphatic pumping and lymph transport. This review summarizes and critiques the evidence for the expression of specific KATP channel subunits in lymphatic smooth muscle and endothelium, the roles that they play in normal lymphatic function, and their possible involvement in multiple diseases, including metabolic syndrome, lymphedema, and Cantú syndrome. For each of these topics, suggestions are made for directions for future research.

Original languageEnglish
Pages (from-to)C1018-C1035
JournalAmerican Journal of Physiology - Cell Physiology
Issue number4
StatePublished - Oct 2022


  • Cantú syndrome
  • KABCC9
  • KCNJ8
  • lymphedema
  • metabolic syndrome


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