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Abstract

In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular basis of channel activity. In parallel, the uncovering of disease-causing mutations of KATP has led to an explanation of the molecular basis of disease and, in turn, to a better understanding of the structural basis of channel function.

Original languageEnglish
Pages (from-to)470-476
Number of pages7
JournalNature
Volume440
Issue number7083
DOIs
StatePublished - Mar 23 2006

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