KATP channelopathies in the pancreas

Maria S. Remedi, Joseph C. Koster

Research output: Contribution to journalReview article

34 Scopus citations

Abstract

Adenosine-triphosphate-sensitive potassium channels (KATP) are regulated by adenosine nucleotides, and, thereby, couple cellular metabolism with electrical activity in multiple tissues including the pancreatic â-cell. The critical involvement of KATP in insulin secretion is confirmed by the demonstration that inactivating and activating mutations in KATP underlie persistent hyperinsulinemia and neonatal diabetes mellitus, respectively, in both animal models and humans. In addition, a common variant in KATP represents a risk factor in the etiology of type 2 diabetes. This review focuses on the mechanistic basis by which KATP mutations underlie insulin secretory disorders and the implications of these findings for successful clinical intervention.

Original languageEnglish
Pages (from-to)307-320
Number of pages14
JournalPflugers Archiv European Journal of Physiology
Volume460
Issue number2
DOIs
StatePublished - Jul 2010

Keywords

  • Diazoxide
  • Hyperinsulinism
  • Kir6.2
  • Neonatal diabetes
  • SUR1
  • Sulfonylurea

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