Knowledge management and informatics considerations for comparative effectiveness research: A case-driven exploration

Peter J. Embi, Courtney Hebert, Gayle Gordillo, Kelly Kelleher, Philip R.O. Payne

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

BACKGROUND: As clinical data are increasingly collected and stored electronically, their potential use for comparative effectiveness research (CER) grows. Despite this promise, challenges face those wishing to leverage such data. In this paper we aim to enumerate some of the knowledge management and informatics issues common to such data reuse. DESIGN: After reviewing the current state of knowledge regarding biomedical informatics challenges and best practices related to CER, we then present 2 research projects at our institution. We analyze these and highlight several common themes and challenges related to the conduct of CER studies. Finally, we represent these emergent themes. RESULTS: The informatics challenges commonly encountered by those conducting CER studies include issues related to data information and knowledge management (eg, data reuse, data preparation) as well as those related to people and organizational issues (eg, sociotechnical factors and organizational factors). Examples of these are described in further detail and a formal framework for describing these findings is presented. CONCLUSIONS: Significant challenges face researchers attempting to use often diverse and heterogeneous datasets for CER. These challenges must be understood in order to be dealt with successfully and can often be overcome with the appropriate use of informatics best practices. Many research and policy questions remain to be answered in order to realize the full potential of the increasingly electronic clinical data available for such research.

Original languageEnglish
Pages (from-to)S38-S44
JournalMedical care
Volume51
Issue number8 SUPPL.3
DOIs
StatePublished - Aug 2013

Keywords

  • comparative effectiveness research
  • knowledge management
  • medical informatics

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