Klonidin'in sevofluran anestezisi altinda, orta serebral arter akim hizi ve serebrovasküler CO₂ yaniti üzerine etkileri

Aim: In this study we aimed to investigate the effects of klonidin, an α2 adrenergic agonist and used as premedication, on middle cerebral arteria flow rate (Vmca) and cerebrovascular CO₂ response under sevoflurane anaesthesia by transcranial doppler usg. Material and Methods: We had three groups of patients. In Group C (n:12), sevoflurane anaesthesia and oral clonidin tablet (Cateprasan) 75 μg as premedication were used while preoperative placebo tablet and sevoflurane anaesthesia were used in group S (n:12). Group A (n:12) was the control group and no premedication and anaesthesia was applied Middle cerebral arteria flow rate was measured by transcranial doppler usg for all patients in status normocapni, hypocapni and hypercapnia respectively and arterial blood gas was measured same time. Results: Vmca values in group C and S were significantly lower than group A in all states of PaCO₂. In two anaesthesia applied groups, Vmca was significantly lower in clonidin group only in hypercapnia CO₂ response curve was significantly lower in group C when compared with group A and B. Conclusion: According to our results, clonidin as an oral premadicant agent, is an appropriate drug for cranial surgery as it decreases Vmca and cerebrovascular CO₂ response under sevoflurane anaesthesia and hypercapni.