TY - JOUR
T1 - Klebsiella pneumoniae
T2 - adaptive immune landscapes and vaccine horizons
AU - Wantuch, Paeton L.
AU - Rosen, David A.
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/10
Y1 - 2023/10
N2 - Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the globe. Despite its clinical importance, we are only beginning to understand how the mammalian adaptive immune system responds to this pathogen. Further, many studies investigating potential K. pneumoniae vaccine candidates or alternative therapies have been launched in recent years. Here, we review the current state of knowledge on the adaptive immune response to K. pneumoniae infections and progress towards developing vaccines and other therapies to combat these infections.
AB - Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the globe. Despite its clinical importance, we are only beginning to understand how the mammalian adaptive immune system responds to this pathogen. Further, many studies investigating potential K. pneumoniae vaccine candidates or alternative therapies have been launched in recent years. Here, we review the current state of knowledge on the adaptive immune response to K. pneumoniae infections and progress towards developing vaccines and other therapies to combat these infections.
KW - Klebsiella pneumoniae
KW - adaptive immunity
KW - bioconjugate vaccine
KW - conjugate vaccine
KW - monoclonal antibodies
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=85170528776&partnerID=8YFLogxK
U2 - 10.1016/j.it.2023.08.005
DO - 10.1016/j.it.2023.08.005
M3 - Review article
C2 - 37704549
AN - SCOPUS:85170528776
SN - 1471-4906
VL - 44
SP - 826
EP - 844
JO - Trends in Immunology
JF - Trends in Immunology
IS - 10
ER -