Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood mortality across the globe. Despite its clinical importance, we are only beginning to understand how the mammalian adaptive immune system responds to this pathogen. Further, many studies investigating potential K. pneumoniae vaccine candidates or alternative therapies have been launched in recent years. Here, we review the current state of knowledge on the adaptive immune response to K. pneumoniae infections and progress towards developing vaccines and other therapies to combat these infections.

Original languageEnglish
Pages (from-to)826-844
Number of pages19
JournalTrends in Immunology
Issue number10
StatePublished - Oct 2023


  • adaptive immunity
  • bioconjugate vaccine
  • conjugate vaccine
  • Klebsiella pneumoniae
  • monoclonal antibodies
  • vaccine


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