Kingdom-agnostic metagenomics and the importance of complete characterization of enteric microbial communities

Jason M. Norman, Scott A. Handley, Herbert W. Virgin

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Advanced sequencing techniques have shown that bacteria are not the only complex and important microbes in the human intestine. Nonbacterial organisms, particularly the virome and the mycobiome, are important regulators of intestinal immunity and inflammation. The virome is mucosal and systemic; it can alter the host response to bacteria and interact with host genes and bacteria to contribute to disease pathogenesis. The human mycobiome is also complex and can contribute to intestinal inflammation. We review what has recently been learned about the nonbacterial and nonarchaeal microbes in the gastrointestinal tract, discussing their potential effects on health and disease and analytical approaches for their study. Studies of associations between the microbiome and intestinal pathology should incorporate kingdom-agnostic approaches if we are to fully understand intestinal health and disease.

Original languageEnglish
Pages (from-to)1459-1469
Number of pages11
JournalGastroenterology
Volume146
Issue number6
DOIs
StatePublished - May 2014

Keywords

  • Metagenomics
  • Mycobiome
  • Virome

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