Kidney transplantation in pediatric patients with rheumatologic disorders

Ellen Cody, David K. Hooper

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of reviewProviders caring for children with end-stage kidney disease from rheumatologic conditions face questions such as when to proceed with kidney transplantation, how common is disease recurrence posttransplant, how does recurrent disease impact patient and allograft outcomes, and what approaches are available to prevent and treat recurrent disease. We discuss recent developments and relevant literature that address these questions for the most common rheumatologic disorders that lead to end-stage kidney disease in childhood namely, systemic lupus erythematosus, IgA nephropathy, IgA Vasculitis/Henoch Schoenlein Purpura, and Anti-Neutrophil Cytoplasmic Antibody (ANCA)-associated vasculitis.Recent findingsRecent data suggest that children with IgA nephropathy, IgA vasculitis, and ANCA-associated vasculitis have similar patient and allograft survival to other conditions despite the risk of recurrent disease, yet those with lupus have worse posttransplant patient and allograft outcomes. A period of disease quiescence may be prudent prior to transplantation to decrease the risk of recurrence, which is associated with decreased allograft survival. Data on preventive strategies and treatment options are limited.SummaryIt is recommended that patients with systemic rheumatologic conditions not be excluded from kidney transplantation but that patients be counseled on the risk of potential recurrent disease with its impact on transplant outcomes.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalCurrent opinion in pediatrics
Volume34
Issue number2
DOIs
StatePublished - Apr 1 2022

Keywords

  • anti-neutrophil cytoplasmic antibody ANCA
  • IgA
  • IgAV
  • pediatric
  • rheumatologic
  • systemic lupus erythematosus
  • transplant

Fingerprint

Dive into the research topics of 'Kidney transplantation in pediatric patients with rheumatologic disorders'. Together they form a unique fingerprint.

Cite this