TY - JOUR
T1 - Kidney repair and regeneration
T2 - perspectives of the NIDDK (Re)Building a Kidney consortium
AU - Naved, Bilal A.
AU - Bonventre, Joseph V.
AU - Hubbell, Jeffrey A.
AU - Hukriede, Neil A.
AU - Humphreys, Benjamin D.
AU - Kesselman, Carl
AU - Valerius, M. Todd
AU - McMahon, Andrew P.
AU - Shankland, Stuart J.
AU - Wertheim, Jason A.
AU - White, Michael J.V.
AU - de Caestecker, Mark P.
AU - Drummond, Iain A.
N1 - Publisher Copyright:
© 2022 International Society of Nephrology
PY - 2022/5
Y1 - 2022/5
N2 - Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can lead to chronic inflammation and fibrosis. However, factors enabling productive repair versus nonproductive, persistent injury states remain less understood. The (Re)Building a Kidney (RBK) consortium is a National Institute of Diabetes and Digestive and Kidney Diseases consortium focused on both endogenous kidney repair mechanisms and the generation of new kidney tissue. This short review provides an update on RBK studies of endogenous nephron repair, addressing the following questions: (i) What is productive nephron repair? (ii) What are the cellular sources and drivers of repair? and (iii) How do RBK studies promote development of therapeutics? Also, we provide a guide to RBK's open access data hub for accessing, downloading, and further analyzing data sets.
AB - Acute kidney injury impacts ∼13.3 million individuals and causes ∼1.7 million deaths per year globally. Numerous injury pathways contribute to acute kidney injury, including cell cycle arrest, senescence, inflammation, mitochondrial dysfunction, and endothelial injury and dysfunction, and can lead to chronic inflammation and fibrosis. However, factors enabling productive repair versus nonproductive, persistent injury states remain less understood. The (Re)Building a Kidney (RBK) consortium is a National Institute of Diabetes and Digestive and Kidney Diseases consortium focused on both endogenous kidney repair mechanisms and the generation of new kidney tissue. This short review provides an update on RBK studies of endogenous nephron repair, addressing the following questions: (i) What is productive nephron repair? (ii) What are the cellular sources and drivers of repair? and (iii) How do RBK studies promote development of therapeutics? Also, we provide a guide to RBK's open access data hub for accessing, downloading, and further analyzing data sets.
KW - acute kidney injury
KW - cell signaling
KW - fibrosis
KW - glomerulus
KW - inflammation
KW - proximal tubule
UR - http://www.scopus.com/inward/record.url?scp=85127465362&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2022.02.023
DO - 10.1016/j.kint.2022.02.023
M3 - Article
C2 - 35276204
AN - SCOPUS:85127465362
SN - 0085-2538
VL - 101
SP - 845
EP - 853
JO - Kidney International
JF - Kidney International
IS - 5
ER -