TY - JOUR
T1 - Kidney disease in HIV-infected patients
AU - Scarpino, M.
AU - Pinzone, M. R.
AU - Di Rosa, M.
AU - Madeddu, G.
AU - Focà, E.
AU - Martellotta, F.
AU - Schioppa, O.
AU - Ceccarelli, G.
AU - Celesia, B. M.
AU - D'Ettorre, G.
AU - Vullo, V.
AU - Berretta, S.
AU - Cacopardo, B.
AU - Nunnari, G.
PY - 2013
Y1 - 2013
N2 - The introduction of highly active antiretroviral therapy (HAART) has reduced mortality and improved life expectancy of HIV-positive patients. However, increased survival is associated with increased prevalence of comorbidities, such as cardiovascular disease, hepatic and renal disease. Kidney disease, including HIV-associated nephropathy, acute renal failure and chronic kidney disease, represents one of the main causes of morbidity and mortality, especially if associated to other risk factors, i.e. hypertension, diabetes, older age, black race and hepatitis C coinfection. Careful evaluation of renal function may help identifying kidney disease in its early stages. In addition, proper management of hypertension and diabetes is recommended. Even if HAART has changed the natural course of HIV-associated nephropathy, reducing the risk of End-stage Renal Disease (ERDS), some antiretroviral regimens have been related with the development of acute or chronic kidney disease. Further studies are needed to optimize the management of renal disease among HIV-infected patients.
AB - The introduction of highly active antiretroviral therapy (HAART) has reduced mortality and improved life expectancy of HIV-positive patients. However, increased survival is associated with increased prevalence of comorbidities, such as cardiovascular disease, hepatic and renal disease. Kidney disease, including HIV-associated nephropathy, acute renal failure and chronic kidney disease, represents one of the main causes of morbidity and mortality, especially if associated to other risk factors, i.e. hypertension, diabetes, older age, black race and hepatitis C coinfection. Careful evaluation of renal function may help identifying kidney disease in its early stages. In addition, proper management of hypertension and diabetes is recommended. Even if HAART has changed the natural course of HIV-associated nephropathy, reducing the risk of End-stage Renal Disease (ERDS), some antiretroviral regimens have been related with the development of acute or chronic kidney disease. Further studies are needed to optimize the management of renal disease among HIV-infected patients.
KW - ARF
KW - CKD
KW - HAART
KW - HIV
KW - HIVAN
KW - Kidney
UR - http://www.scopus.com/inward/record.url?scp=84886619862&partnerID=8YFLogxK
M3 - Article
C2 - 24142615
AN - SCOPUS:84886619862
SN - 1128-3602
VL - 17
SP - 2660
EP - 2667
JO - European Review for Medical and Pharmacological Sciences
JF - European Review for Medical and Pharmacological Sciences
IS - 19
ER -