Kidney disease associated with plasma cell dyscrasias

Eliot C. Heher, Nelson B. Goes, Thomas R. Spitzer, Noopur S. Raje, Benjamin D. Humphreys, Kenneth C. Anderson, Paul G. Richardson

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.

Original languageEnglish
Pages (from-to)1397-1404
Number of pages8
JournalBlood
Volume116
Issue number9
DOIs
StatePublished - Sep 2 2010
Externally publishedYes

Fingerprint Dive into the research topics of 'Kidney disease associated with plasma cell dyscrasias'. Together they form a unique fingerprint.

  • Cite this

    Heher, E. C., Goes, N. B., Spitzer, T. R., Raje, N. S., Humphreys, B. D., Anderson, K. C., & Richardson, P. G. (2010). Kidney disease associated with plasma cell dyscrasias. Blood, 116(9), 1397-1404. https://doi.org/10.1182/blood-2010-03-258608