Kidney disease associated with plasma cell dyscrasias

Eliot C. Heher; Nelson B. Goes; Thomas R. Spitzer; Noopur S. Raje; Benjamin D. Humphreys; Kenneth C. Anderson; Paul G. Richardson

doi:10.1182/blood-2010-03-258608

Kidney disease associated with plasma cell dyscrasias

Eliot C. Heher, Nelson B. Goes, Thomas R. Spitzer, Noopur S. Raje, Benjamin D. Humphreys, Kenneth C. Anderson, Paul G. Richardson

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.

Original language	English
Pages (from-to)	1397-1404
Number of pages	8
Journal	Blood
Volume	116
Issue number	9
DOIs	https://doi.org/10.1182/blood-2010-03-258608
State	Published - Sep 2 2010

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title = "Kidney disease associated with plasma cell dyscrasias",

abstract = "Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.",

author = "Heher, {Eliot C.} and Goes, {Nelson B.} and Spitzer, {Thomas R.} and Raje, {Noopur S.} and Humphreys, {Benjamin D.} and Anderson, {Kenneth C.} and Richardson, {Paul G.}",

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T1 - Kidney disease associated with plasma cell dyscrasias

AU - Heher, Eliot C.

AU - Goes, Nelson B.

AU - Spitzer, Thomas R.

AU - Raje, Noopur S.

AU - Humphreys, Benjamin D.

AU - Anderson, Kenneth C.

AU - Richardson, Paul G.

PY - 2010/9/2

Y1 - 2010/9/2

N2 - Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.

AB - Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.

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U2 - 10.1182/blood-2010-03-258608

DO - 10.1182/blood-2010-03-258608

M3 - Review article

C2 - 20462963

AN - SCOPUS:77956590903

SN - 0006-4971

VL - 116

SP - 1397

EP - 1404

JO - Blood

JF - Blood

IS - 9

ER -

Kidney disease associated with plasma cell dyscrasias

Abstract

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