9 Scopus citations

Abstract

Single-cell RNA sequencing (scRNA-seq) technologies are increasingly being applied to reveal cellular heterogeneity in kidney development and disease. In just the last year, multiple scRNA-seq datasets have been generated from kidney organoids, developing mouse and human kidney, adult kidney, and kidney cancer. The data generated enables a much deeper understanding of biological processes within and between cells. It has also elucidated unforeseen cell lineage relationships, defined the presence of off-target cell types in kidney organoids, and revealed a diverse inflammatory response in a human kidney allograft undergoing rejection. This review summarizes the recent rapid progress in scRNA-seq of the kidney and outlines future directions for single-cell technologies as applied to the kidney.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalPediatric Nephrology
Volume35
Issue number2
DOIs
StatePublished - Feb 1 2020

Keywords

  • Informatics
  • Next-generation sequencing
  • Organoids
  • Single cell
  • Stem cell
  • Transcriptomics

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