TY - JOUR
T1 - KHARON1 mediates flagellar targeting of a glucose transporter in Leishmania mexicana and is critical for viability of infectious intracellular amastigotes
AU - Tran, Khoa D.
AU - Rodriguez-Contreras, Dayana
AU - Vieira, Danielle P.
AU - Yates, Phillip A.
AU - David, Larry
AU - Beatty, Wandy
AU - Elferich, Johannes
AU - Landfear, Scott M.
PY - 2013/8/2
Y1 - 2013/8/2
N2 - Background: The mechanism for selectively targeting membrane proteins to the flagellum of kinetoplastid parasites is unknown. Results: We have identified a novel protein, KHARON1, which is important for the flagellar targeting of a glucose transporter. Conclusion: KHARON1 is the first protein identified in Kinetoplastida that targets a membrane protein to the flagellum. Significance: KHARON1 may be part of a new flagellar targeting pathway.
AB - Background: The mechanism for selectively targeting membrane proteins to the flagellum of kinetoplastid parasites is unknown. Results: We have identified a novel protein, KHARON1, which is important for the flagellar targeting of a glucose transporter. Conclusion: KHARON1 is the first protein identified in Kinetoplastida that targets a membrane protein to the flagellum. Significance: KHARON1 may be part of a new flagellar targeting pathway.
UR - http://www.scopus.com/inward/record.url?scp=84881221113&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.483461
DO - 10.1074/jbc.M113.483461
M3 - Article
C2 - 23766511
AN - SCOPUS:84881221113
VL - 288
SP - 22721
EP - 22733
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 31
ER -