Keeping time in group 3 innate lymphoid cells

Qianli Wang, Marco Colonna

Research output: Contribution to journalArticlepeer-review

Abstract

Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s. We discuss how these studies have illustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the implications for intestinal immunity.

Original languageEnglish
Pages (from-to)720-726
Number of pages7
JournalNature Reviews Immunology
Volume20
Issue number12
DOIs
StatePublished - Dec 2020

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