TY - JOUR
T1 - Keeping time in group 3 innate lymphoid cells
AU - Wang, Qianli
AU - Colonna, Marco
N1 - Publisher Copyright:
© 2020, Springer Nature Limited.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s. We discuss how these studies have illustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the implications for intestinal immunity.
AB - Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s. We discuss how these studies have illustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the implications for intestinal immunity.
UR - http://www.scopus.com/inward/record.url?scp=85089067983&partnerID=8YFLogxK
U2 - 10.1038/s41577-020-0397-z
DO - 10.1038/s41577-020-0397-z
M3 - Article
C2 - 32759971
AN - SCOPUS:85089067983
VL - 20
SP - 720
EP - 726
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
SN - 1474-1733
IS - 12
ER -