TY - JOUR
T1 - Keeping time in group 3 innate lymphoid cells
AU - Wang, Qianli
AU - Colonna, Marco
N1 - Funding Information:
M.C. receives research support from Pfizer. Q.W. declares no competing interests.
Funding Information:
The authors thank S. Gilfillan and B. Bhattarai for helpful feedback. This work was supported by National Institutes of Health (NIH) grants AI095542, DE025884, AI134236 and AI134035 (to M.C.) and T32 GM007200 (to Q.W.). M.C. receives research support from Pfizer, Crohn’s & Colitis Foundation and an anonymous donor in New York.
Publisher Copyright:
© 2020, Springer Nature Limited.
PY - 2020/12
Y1 - 2020/12
N2 - Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s. We discuss how these studies have illustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the implications for intestinal immunity.
AB - Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s. We discuss how these studies have illustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the implications for intestinal immunity.
UR - http://www.scopus.com/inward/record.url?scp=85089067983&partnerID=8YFLogxK
U2 - 10.1038/s41577-020-0397-z
DO - 10.1038/s41577-020-0397-z
M3 - Article
C2 - 32759971
AN - SCOPUS:85089067983
SN - 1474-1733
VL - 20
SP - 720
EP - 726
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 12
ER -