Keeping an eye on I1:I1 Dynein as a model for flagellar dynein assembly and regulation

Maureen Wirschell, Triscia Hendrickson, Winfield S. Sale

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

Among the major challenges in understanding ciliary and flagellar motility is to determine how the dynein motors are assembled and localized and how dynein-driven outer doublet microtubule sliding is controlled. Diverse studies, particularly in Chlamydomonas, have determined that the inner arm dynein I1 is targeted to a unique structural position and is critical for regulating the microtubule sliding required for normal ciliary/flagellar bending. As described in this review, I1 dynein offers additional opportunities to determine the principles of assembly and targeting of dyneins to cellular locations and for studying the mechanisms that regulate dynein activity and control of motility by phosphorylation.

Original languageEnglish
Pages (from-to)569-579
Number of pages11
JournalCell Motility and the Cytoskeleton
Volume64
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • Axoneme
  • Cilia
  • F-dynein
  • Flagella
  • I1 dynein

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