Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field

Aurelio Bonavia; Samuel R. Dominguez; Gabriela Dveksler; Sara Gagneten; Megan Howard; Scott Jeffers; Zhaohui Qian; Mary Kathryn Smith; Larissa B. Thackray; Dina B. Tresnan; David E. Wentworth; David R. Wessner; Richard K. Williams; Tanya A. Miura

doi:10.3390/v14071573

Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field

Aurelio Bonavia, Samuel R. Dominguez, Gabriela Dveksler, Sara Gagneten, Megan Howard, Scott Jeffers, Zhaohui Qian, Mary Kathryn Smith, Larissa B. Thackray, Dina B. Tresnan, David E. Wentworth, David R. Wessner, Richard K. Williams, Tanya A. Miura

Division of Infectious Diseases

Research output: Contribution to journal › Review article › peer-review

Abstract

Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on coronaviruses developed over decades by researchers, including Kathryn (Kay) Holmes. Kay’s research team discovered the first coronavirus receptors for mouse hepatitis virus and human coronavirus 229E and contributed a wealth of information on coronaviral spike glycoproteins and receptor interactions that are critical determinants of host and tissue specificity. She collaborated with several research laboratories to contribute knowledge in additional areas, including coronaviral pathogenesis, epidemiology, and evolution. Throughout her career, Kay was an extremely dedicated and thoughtful mentor to numerous graduate students and post-doctoral fellows. This article provides a review of her contributions to the coronavirus field and her exemplary mentoring.

Original language	English
Article number	1573
Journal	Viruses
Volume	14
Issue number	7
DOIs	https://doi.org/10.3390/v14071573
State	Published - Jul 2022

Keywords

coronavirus
coronavirus receptors
coronavirus spike glycoprotein

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10.3390/v14071573

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title = "Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field",

abstract = "Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on coronaviruses developed over decades by researchers, including Kathryn (Kay) Holmes. Kay{\textquoteright}s research team discovered the first coronavirus receptors for mouse hepatitis virus and human coronavirus 229E and contributed a wealth of information on coronaviral spike glycoproteins and receptor interactions that are critical determinants of host and tissue specificity. She collaborated with several research laboratories to contribute knowledge in additional areas, including coronaviral pathogenesis, epidemiology, and evolution. Throughout her career, Kay was an extremely dedicated and thoughtful mentor to numerous graduate students and post-doctoral fellows. This article provides a review of her contributions to the coronavirus field and her exemplary mentoring.",

keywords = "coronavirus, coronavirus receptors, coronavirus spike glycoprotein",

author = "Aurelio Bonavia and Dominguez, {Samuel R.} and Gabriela Dveksler and Sara Gagneten and Megan Howard and Scott Jeffers and Zhaohui Qian and Smith, {Mary Kathryn} and Thackray, {Larissa B.} and Tresnan, {Dina B.} and Wentworth, {David E.} and Wessner, {David R.} and Williams, {Richard K.} and Miura, {Tanya A.}",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = jul,

doi = "10.3390/v14071573",

language = "English",

volume = "14",

journal = "Viruses",

issn = "1999-4915",

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T2 - A Career of Contributions to the Coronavirus Field

AU - Bonavia, Aurelio

AU - Dominguez, Samuel R.

AU - Dveksler, Gabriela

AU - Gagneten, Sara

AU - Howard, Megan

AU - Jeffers, Scott

AU - Qian, Zhaohui

AU - Smith, Mary Kathryn

AU - Thackray, Larissa B.

AU - Tresnan, Dina B.

AU - Wentworth, David E.

AU - Wessner, David R.

AU - Williams, Richard K.

AU - Miura, Tanya A.

PY - 2022/7

Y1 - 2022/7

N2 - Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on coronaviruses developed over decades by researchers, including Kathryn (Kay) Holmes. Kay’s research team discovered the first coronavirus receptors for mouse hepatitis virus and human coronavirus 229E and contributed a wealth of information on coronaviral spike glycoproteins and receptor interactions that are critical determinants of host and tissue specificity. She collaborated with several research laboratories to contribute knowledge in additional areas, including coronaviral pathogenesis, epidemiology, and evolution. Throughout her career, Kay was an extremely dedicated and thoughtful mentor to numerous graduate students and post-doctoral fellows. This article provides a review of her contributions to the coronavirus field and her exemplary mentoring.

AB - Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on coronaviruses developed over decades by researchers, including Kathryn (Kay) Holmes. Kay’s research team discovered the first coronavirus receptors for mouse hepatitis virus and human coronavirus 229E and contributed a wealth of information on coronaviral spike glycoproteins and receptor interactions that are critical determinants of host and tissue specificity. She collaborated with several research laboratories to contribute knowledge in additional areas, including coronaviral pathogenesis, epidemiology, and evolution. Throughout her career, Kay was an extremely dedicated and thoughtful mentor to numerous graduate students and post-doctoral fellows. This article provides a review of her contributions to the coronavirus field and her exemplary mentoring.

KW - coronavirus

KW - coronavirus receptors

KW - coronavirus spike glycoprotein

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DO - 10.3390/v14071573

M3 - Review article

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SN - 1999-4915

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JO - Viruses

JF - Viruses

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M1 - 1573

ER -

Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field

Abstract

Keywords

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