Karyopherins: From nuclear-transport mediators to nuclear-function regulators

Nima Mosammaparast, Lucy F. Pemberton

Research output: Contribution to journalReview articlepeer-review

266 Scopus citations

Abstract

The karyopherin β (or importin β) family comprises soluble transport factors that mediate the movement of proteins and RNAs between the nucleus and cytoplasm. Recent studies have extended the role of karyopherins to regulating assembly of the nuclear pore complex (NPC), assembly of the nuclear envelope, mitosis and replication. New data also address how karyopherins specifically recognize and transport many distinct cargoes and traverse the NPC. These data raise the possibility that, although there might be a universal mechanism for nuclear transport, specific interactions between karyopherins and components of the NPC might function to regulate differentially the ability of the different karyopherins to cross the NPC.

Original languageEnglish
Pages (from-to)547-556
Number of pages10
JournalTrends in Cell Biology
Volume14
Issue number10
DOIs
StatePublished - Oct 2004

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