Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord

Ping Li, Timothy J. Wilding, Susan J. Kim, Amelita A. Calejesan, James E. Huettner, Min Zhuo

Research output: Contribution to journalArticle

228 Scopus citations

Abstract

Glutamate, the major excitatory neurotransmitter in the central nervous system, activates three different receptors that directly gate ion channels, namely receptors for AMPA (α-amino-3-hydroxy-5-methyl isoxozole propionic acid), NMDA (N-methyl-D-aspartate), and kainate, a structural analogue of glutamate. The contribution of AMPA and NMDA receptors to synaptic transmission and plasticity is well established. Recent work on the physiological function of kainate receptors has focused on the hippocampus, where repetitive activation of the mossy-fibre pathway generates a slow, kainate-receptor-mediated excitatory postsynaptic current (EPSC). Here we show that high-intensity single-shock stimulation (of duration 200 microseconds) of primary afferent sensory fibres produces a fast, kainate- receptor-mediated EPSC in the superficial dorsal horn of the spinal cord. Activation of low-threshold afferent fibres generates typical AMPA-receptor- mediated EPSCs only, indicating that kainate receptors may he restricted to synapses formed by high-threshold nociceptive (pain-sensing) and thermoreceptive primary afferent fibres. Consistent with this possibility, kainate-receptor-mediated EPSCs are blocked by the analgesic μ-opiate- receptor agonist Damgo and spinal blockade of both kainate and AMPA receptors produces antinociception. Thus, spinal kainate receptors contribute to transmission of somatosensory inputs from the periphery to the brain.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalNature
Volume397
Issue number6715
DOIs
StatePublished - Jan 14 1999

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    Li, P., Wilding, T. J., Kim, S. J., Calejesan, A. A., Huettner, J. E., & Zhuo, M. (1999). Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature, 397(6715), 161-164. https://doi.org/10.1038/16469