Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment

Alberto J. Espay; Dominic C. Paviour; John D. O'Sullivan; Robert E. Schmidt; Fredy J. Revilla; Leo Verhagen Metman

doi:10.1002/mds.23194

Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment

Alberto J. Espay, Dominic C. Paviour, John D. O'Sullivan, Robert E. Schmidt, Fredy J. Revilla, Leo Verhagen Metman

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.

Original language	English
Pages (from-to)	1860-1867
Number of pages	8
Journal	Movement Disorders
Volume	25
Issue number	12
DOIs	https://doi.org/10.1002/mds.23194
State	Published - Sep 15 2010

Keywords

Juvenile Parkinsonism
Neuronal intranuclear inclusion disease
Parkinsonism pathology

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10.1002/mds.23194

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title = "Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment",

abstract = "A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.",

keywords = "Juvenile Parkinsonism, Neuronal intranuclear inclusion disease, Parkinsonism pathology",

author = "Espay, {Alberto J.} and Paviour, {Dominic C.} and O'Sullivan, {John D.} and Schmidt, {Robert E.} and Revilla, {Fredy J.} and Metman, {Leo Verhagen}",

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AU - Espay, Alberto J.

AU - Paviour, Dominic C.

AU - O'Sullivan, John D.

AU - Schmidt, Robert E.

AU - Revilla, Fredy J.

AU - Metman, Leo Verhagen

PY - 2010/9/15

Y1 - 2010/9/15

N2 - A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.

AB - A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.

KW - Juvenile Parkinsonism

KW - Neuronal intranuclear inclusion disease

KW - Parkinsonism pathology

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JO - Movement Disorders

JF - Movement Disorders

IS - 12

ER -

Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment

Abstract

Keywords

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