Juvenile levodopa-responsive Parkinsonism with early orobuccolingual dyskinesias and cognitive impairment

Alberto J. Espay, Dominic C. Paviour, John D. O'Sullivan, Robert E. Schmidt, Fredy J. Revilla, Leo Verhagen Metman

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

A 13-year old girl presented with slowly progressive rest tremor of the hands, bradykinesia, and rigidity. The symptoms improved with dopaminergic medications, but severe drug-induced dyskinesias developed early. She subsequently developed cognitive slowing and difficulty initiating saccadic eye movements. She went on to have deep brain stimulation surgery. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.

Original languageEnglish
Pages (from-to)1860-1867
Number of pages8
JournalMovement Disorders
Volume25
Issue number12
DOIs
StatePublished - Sep 15 2010

Keywords

  • Juvenile Parkinsonism
  • Neuronal intranuclear inclusion disease
  • Parkinsonism pathology

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