Jurassic PARK2: You eat your mitochondria, and you are what your mitochondria eat

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

ABSTRACT: Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.

Original languageEnglish
Pages (from-to)610-611
Number of pages2
JournalAutophagy
Volume12
Issue number3
DOIs
StatePublished - Jan 1 2016

Keywords

  • Heart
  • Parkin
  • metabolomics
  • mitofusin 2
  • mitophagy
  • transcriptomics

Fingerprint Dive into the research topics of 'Jurassic PARK2: You eat your mitochondria, and you are what your mitochondria eat'. Together they form a unique fingerprint.

  • Cite this