Jurassic PARK2: You eat your mitochondria, and you are what your mitochondria eat

Gerald W. Dorn

doi:10.1080/15548627.2016.1143210

Jurassic PARK2: You eat your mitochondria, and you are what your mitochondria eat

Gerald W. Dorn

Research output: Contribution to journal › Comment/debate

5 Scopus citations

Abstract

ABSTRACT: Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.

Original language	English
Pages (from-to)	610-611
Number of pages	2
Journal	Autophagy
Volume	12
Issue number	3
DOIs	https://doi.org/10.1080/15548627.2016.1143210
State	Published - 2016

Keywords

Heart
Parkin
metabolomics
mitofusin 2
mitophagy
transcriptomics

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10.1080/15548627.2016.1143210

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abstract = "ABSTRACT: Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.",

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AB - ABSTRACT: Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.

KW - Heart

KW - Parkin

KW - metabolomics

KW - mitofusin 2

KW - mitophagy

KW - transcriptomics

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DO - 10.1080/15548627.2016.1143210

M3 - Comment/debate

C2 - 26854000

AN - SCOPUS:84962733957

SN - 1554-8627

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SP - 610

EP - 611

JO - Autophagy

JF - Autophagy

IS - 3

ER -

Jurassic PARK2: You eat your mitochondria, and you are what your mitochondria eat

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Keywords

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